Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Osteogenic protein-1 (OP-1) blocks cartilage damage caused by fibronectin fragments and promotes repair by enhancing proteoglycan synthesis
Autore:
Koepp, HE; Sampath, KT; Kuettner, KE; Homandberg, GA;
Indirizzi:
RushLMed Coll, Dept Biochem, Rush Presbyterian St Lukes Med Ctr, Chicago, I Rush Med Coll Chicago IL USA 60612 sbyterian St Lukes Med Ctr, Chicago, I Univ Ulm, Dept Orthopaed Surg, D-89081 Ulm, Germany Univ Ulm Ulm GermanyD-89081 , Dept Orthopaed Surg, D-89081 Ulm, Germany Creat BioMol, Hopkinton, MA USA Creat BioMol Hopkinton MA USACreat BioMol, Hopkinton, MA USA
Titolo Testata:
INFLAMMATION RESEARCH
fascicolo: 4, volume: 48, anno: 1999,
pagine: 199 - 204
SICI:
1023-3830(199904)48:4<199:OP(BCD>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA; HUMAN ARTICULAR CHONDROCYTES; TGF-BETA; CHONDROLYSIS; DEGRADATION; INHIBITION; RELEASE; DIFFERENTIATION; INTERLEUKIN-1; ANTIOXIDANTS;
Keywords:
OP-1; TGF-beta; fibronectin fragments; cartilage; cartilage repair;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Homandberg, GA RushgressColl, Dept Biochem, Rush Presbyterian St Lukes MedCtr, 1653 W Con Rush Med Coll 1653 W Congress Pkwy Chicago IL USA 60612 Con
Citazione:
H.E. Koepp et al., "Osteogenic protein-1 (OP-1) blocks cartilage damage caused by fibronectin fragments and promotes repair by enhancing proteoglycan synthesis", INFLAMM RES, 48(4), 1999, pp. 199-204

Abstract

Objective and Design: The abilities of osteogenic protein-1 (OP-l) and TGF-beta 1 to affect cartilage damage caused by fibronectin fragments (Fn-fs) that are known to greatly enhance cartilage proteoglycan (PG) degradation were compared. Material. Articular cartilage was obtained from 18 month old bovines. Treatment: To test blocking of damage, cartilage was cultured with or without OP-l or TGF-beta in the presence of 100 nM Fn-fs. To test restoration of PG, cartilage was first cultured with Fn-fs and the cartilage then treated with factors. Methods: Cartilage PG content was measured in papain digests using the dimethylmethylene blue assay. PG synthesis was measured by incorporation of S-35 labeled sulfate. Results. OP-l blocked damage and restored PG in damaged cartilage, apparently due to enhanced PG synthesis. However, TGF-beta 1 alone decreased PG content. Conclusions: These results clearly demonstrate differences between OP-l and TGF-beta 1, both members of the TGF-beta superfamily and illustrate the efficacy of OP-l in blocking Fn-f mediated damage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/08/20 alle ore 20:01:13