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Titolo:
Hippocampal lesions interfere with Pavlovian negative occasion setting
Autore:
Holland, PEC; Lamoureux, JA; Han, JS; Gallagher, M;
Indirizzi:
Duke Univ, Dept Expt Psychol, Durham, NC 27712 USA Duke Univ Durham NC USA 27712 iv, Dept Expt Psychol, Durham, NC 27712 USA Johns Hopkins Univ, Dept Psychol, Baltimore, MD 21218 USA Johns Hopkins Univ Baltimore MD USA 21218 sychol, Baltimore, MD 21218 USA
Titolo Testata:
HIPPOCAMPUS
fascicolo: 2, volume: 9, anno: 1999,
pagine: 143 - 157
SICI:
1050-9631(1999)9:2<143:HLIWPN>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONFIGURAL ASSOCIATION THEORY; NEURAL-NETWORK APPROACH; CONDITIONED-STIMULUS; CONTEXT; RATS; DISCRIMINATIONS; INHIBITION; BEHAVIOR; SPECIFICITY; ACQUISITION;
Keywords:
hippocampus; occasion setting; feature positive; feature negative; inhibition; configural learning;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Holland, PEC Duke Univ, Dept Expt Psychol, Box 90086, Durham, NC 27712 USADuke Univ Box 90086 Durham NC USA 27712 Durham, NC 27712 USA
Citazione:
P.E.C. Holland et al., "Hippocampal lesions interfere with Pavlovian negative occasion setting", HIPPOCAMPUS, 9(2), 1999, pp. 143-157

Abstract

Rats were trained with either a serial feature positive (L--> T1+, T-) or a serial feature negative (L--> T1-, T1+) discrimination, intermixed with training on another, nonconditional discrimination (T2 +, N-), using a Pavlovian appetitive conditioning preparation with multiple response measures. Among rats trained with the serial feature positive discrimination, neurotoxic lesions of the hippocampus produced a transient impairment in the acquisition of that discrimination, but did not affect acquisition of the nonconditional discrimination. In contrast, among rats that received serial feature negative discrimination training, hippocampal lesions produced enduring deficits in the acquisition of both discriminations. The results of transfertests indicated that both lesioned and control rats used a conditional learning strategy (occasion setting) to solve the feature positive and featurenegative discriminations. Furthermore, lesioned rats, especially those that received training with the feature negative discrimination, displayed increasingly higher levels of general activity as training progressed. The results suggest that hippocampal lesions particularly interfere with inhibitory learning (negative occasion setting) about both explicit and contextual cues. Hippocampus 1999;9:143-157. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/05/20 alle ore 12:43:40