Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Increased cancer risk among relatives of nonsmoking lung cancer cases
Autore:
Schwartz, AG; Rothrock, M; Yang, P; Swanson, GM;
Indirizzi:
Alleghenyh,niv Hlth Sci, MCP Hahnemann Sch Med, Dept Human Genet, Pittsburg Allegheny Univ Hlth Sci Pittsburgh PA USA d, Dept Human Genet, Pittsburg Mayo Clin, Clin Epidemiol Sect, Rochester, MN USA Mayo Clin Rochester MN USA Clin, Clin Epidemiol Sect, Rochester, MN USA Michigan State Univ, Ctr Canc, E Lansing, MI 48824 USA Michigan State Univ E Lansing MI USA 48824 Canc, E Lansing, MI 48824 USA Michigan State Univ, Coll Human Med, E Lansing, MI 48824 USA Michigan State Univ E Lansing MI USA 48824 n Med, E Lansing, MI 48824 USA
Titolo Testata:
GENETIC EPIDEMIOLOGY
fascicolo: 1, volume: 17, anno: 1999,
pagine: 1 - 15
SICI:
0741-0395(1999)17:1<1:ICRARO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTATHIONE-S-TRANSFERASE; INCREASED FAMILIAL RISK; IOWA-WOMENS-HEALTH; MICROSATELLITE INSTABILITY; CIGARETTE-SMOKING; BREAST-CANCER; GENETIC POLYMORPHISMS; MENDELIAN INHERITANCE; COLORECTAL-CANCER; SUSCEPTIBILITY;
Keywords:
lung cancer; familial aggregation; tobacco exposure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Schwartz, AG Karmanos Canc Inst, Div Epidemiol, 110 E Warren Ave, Detroit,MI 48201 USA Karmanos Canc Inst 110 E Warren Ave Detroit MI USA 48201 USA
Citazione:
A.G. Schwartz et al., "Increased cancer risk among relatives of nonsmoking lung cancer cases", GENET EPID, 17(1), 1999, pp. 1-15

Abstract

Lung cancer has been shown to aggregate in families of nonsmoking lung cancer cases with an earlier age at onset. The current study evaluates whetherrelatives of nonsmoking lung cancer cases are at increased risk of cancersat sites other than lung. Families were identified through 257 population-based, nonsmoking lung cancer cases and 277 population-based, nonsmoking controls residing in metropolitan Detroit. Data were collected for 2,252 relatives of cases and 2,408 relatives of controls. First-degree relatives of nonsmoking lung cancer cases were at 1.52-fold (95% CI, 1.02-2.27) increasedrisk of cancer of the digestive system after adjustment for each relative's age, race, sex, and smoking status. Relative risk estimates also were elevated, but not significantly, for tobacco-related cancers (RR = 1.39) and breast cancer (RR = 1.72). Among first-degree relatives of younger probands (age 40-59), risk was non-significantly increased 72% (95% CI 0.95-3.10) for all cancers combined and 3.14-fold for cancers of the digestive system (95% CI 0.76-12.9). Nonsmoking relatives of cases were at increased risk of all cancer sites combined (RR = 1.32; 95% CI 1.003-1.73), cancers other thanlung (RR = 1.37; 95% CI 1.03-1.82), and digestive system cancers (RR = 2.01; 95% CI 1.20-3.37). These findings of moderate familial aggregation for cancers of the lung, digestive system, breast, and tobacco-related sites suggest that common susceptibility genes may act to increase risk for a variety of cancers in families. Genet. Epidemiol. 17:1-15, 1999. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 10:03:21