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Titolo:
Opposite effects of FGF and BMP-4 on embryonic blood formation: Roles of PV.1 and GATA-2
Autore:
Xu, RH; Ault, KT; Kim, J; Park, MJ; Hwang, YS; Peng, Y; Sredni, D; Kung, HF;
Indirizzi:
NCI, Lab Biochem Physiol, Div Basic Sci, Frederick, MD 21702 USA NCI Frederick MD USA 21702 hysiol, Div Basic Sci, Frederick, MD 21702 USA NCI,evntramural Res Support Program, SAIC Frederick, Frederick Canc Res & D NCI Frederick MD USA 21702 rogram, SAIC Frederick, Frederick Canc Res & D NICHHD, Genet Mol Lab, NIH, Bethesda, MD 20892 USA NICHHD Bethesda MD USA20892 , Genet Mol Lab, NIH, Bethesda, MD 20892 USA Hallym Univ, Coll Med, Dept Biochem, Chun Cheon, South Korea Hallym Univ Chun Cheon South Korea ept Biochem, Chun Cheon, South Korea Kyungpook Natl Univ, Sch Med, Dept Anat, Taegu 700422, South Korea Kyungpook Natl Univ Taegu South Korea 700422 , Taegu 700422, South Korea Bar Ilan Univ, Interdisciplinary Dept, IL-52900 Ramat Gan, Israel Bar IlanUniv Ramat Gan Israel IL-52900 Dept, IL-52900 Ramat Gan, Israel Univ Hong Kong, Inst Mol Biol, Hong Kong, Hong Kong Univ Hong Kong Hong Kong Hong Kong Inst Mol Biol, Hong Kong, Hong Kong
Titolo Testata:
DEVELOPMENTAL BIOLOGY
fascicolo: 2, volume: 208, anno: 1999,
pagine: 352 - 361
SICI:
0012-1606(19990415)208:2<352:OEOFAB>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE MORPHOGENETIC PROTEIN-4; EARLY XENOPUS EMBRYO; HOMEOBOX GENE; HEMATOPOIETIC MESODERM; VENTRAL MESODERM; TGF-BETA; DIFFERENTIAL REGULATION; SIGNALING PATHWAYS; SPEMANN ORGANIZER; CELL DEVELOPMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Kung, HF NCI, Lab Biochem Physiol, Div Basic Sci, Frederick, MD 21702 USA NCI Frederick MD USA 21702 iv Basic Sci, Frederick, MD 21702 USA
Citazione:
R.H. Xu et al., "Opposite effects of FGF and BMP-4 on embryonic blood formation: Roles of PV.1 and GATA-2", DEVELOP BIO, 208(2), 1999, pp. 352-361

Abstract

In adult vertebrates, fibroblast growth factor (FGF) synergizes with many hematopoietic cytokines to stimulate the proliferation of hematopoietic progenitors. In vertebrate development, the FGF signaling pathway is importantin the formation of some derivatives of ventroposterior mesoderm. However,the function of FGF in the specification of the embryonic erythropoietic lineage has remained unclear. Here we address the role of FGF in the specification of the erythropoietic lineage in the Xenopus embryo. We report that ventral injection of embryonic FGF (eFGF) mRNA at as little as 10 pg at thefour-cell stage suppresses ventral blood island (VBI) formation, whereas expression of the dominant negative form of the EGF receptor in the lateral mesoderm, where physiologically no blood tissue is formed, results in a dramatic expansion of the VBI. Similar results were observed in isolated ventral marginal zones and animal caps. Bone morphogenetic protein-4 (BMP-4) is known to induce erythropoiesis in the Xenopus embryo. Therefore, we examined how the BMP-4 and EGF signaling pathways might interact in the decision of ventral mesoderm to form blood. We observed that eFGF inhibits BMP-4-induced erythropoiesis by differentially regulating expression of the BMP-4 downstream effecters GATA-2 and PV.1. GATA-2 which stimulates erythropoiesis, is suppressed by FGF. PV.1, which we demonstrate to inhibit blood development, is enhanced by FGF. Additionally, PV.1 and GATA-2 negatively regulate transcription of each other. Thus, BMP-4 induces two transcription factors which have opposing effects on blood development. The EGF and BMP-4 signaling pathways interact to regulate the specification of the erythropoietic lineage. (C) 1999 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:40:59