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Titolo:
bves: A novel gene expressed during coronary blood vessel development
Autore:
Reese, DE; Zavaljevski, M; Streiff, NL; Bader, D;
Indirizzi:
Vanderbilt Univ, Program Dev Biol, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 Dev Biol, Nashville, TN 37232 USA Vanderbilt Univ, Stahlman Cardiovasc Res Labs, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 Res Labs, Nashville, TN 37232 USA Vanderbilt Univ, Div Cardiol, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 v Cardiol, Nashville, TN 37232 USA
Titolo Testata:
DEVELOPMENTAL BIOLOGY
fascicolo: 1, volume: 209, anno: 1999,
pagine: 159 - 171
SICI:
0012-1606(19990501)209:1<159:BANGED>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR SMOOTH-MUSCLE; NEURAL CREST; HEART; EPICARDIUM; ORIGIN; DIFFERENTIATION; EMBRYOS; CELLS; IDENTIFICATION; MORPHOGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Reese, DE VanderbiltSAniv, Program Dev Biol, 221 Kirkland Hall, Nashville,TN 37232 U Vanderbilt Univ 221 Kirkland Hall Nashville TN USA 37232 37232 U
Citazione:
D.E. Reese et al., "bves: A novel gene expressed during coronary blood vessel development", DEVELOP BIO, 209(1), 1999, pp. 159-171

Abstract

We have used a subtractive method to clone novel messages enriched in the heart. Here we show that one such message, bves (blood vessel/epicardial substance) is a novel protein that is highly conserved between chicken and mouse. The bves message is detected at high levels in early chick hearts. Using anti-Bves antibodies, we show expression in cells of the proepicardial organ, migrating epicardium, epicardial-derived mesenchyme, and smooth muscle of the developing intracardiac arterial system, including the coronary arteries. Our data suggest that Bves is an early marker of developing vascular smooth muscle cells. In addition, the expression pattern of Bves protein reveals the patterning of intracardiac vascular smooth muscle and possible insights into the cellular regulation of smooth muscle differentiation during vasculogenesis. (C) 1999 Academic Press.

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Documento generato il 31/03/20 alle ore 19:39:20