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Titolo:
Amiodarone interaction with beta-blockers - Analysis of the merged EMIAT (European Myocardial Infarct Amiodarone Trial) and CAMIAT (Canadian Amiodarone Myocardial Infarction Trial) databases
Autore:
Boutitie, F; Boissel, JP; Connolly, SJ; Camm, AJ; Cairns, JA; Julian, DG; Gent, M; Janse, NJ; Dorian, P; Frangin, G;
Indirizzi:
Univ Lyon 1, Dept Clin Pharmacol, F-69365 Lyon, France Univ Lyon 1 Lyon France F-69365 ept Clin Pharmacol, F-69365 Lyon, France McMaster Univ, Dept Med, Hamilton, ON, Canada McMaster Univ Hamilton ON Canada er Univ, Dept Med, Hamilton, ON, Canada McMaster Univ, Dept Clin Epidemiol & Biostat, Hamilton, ON, Canada McMaster Univ Hamilton ON Canada idemiol & Biostat, Hamilton, ON, Canada Univ Toronto, Dept Med, Toronto, ON, Canada Univ Toronto Toronto ON Canada iv Toronto, Dept Med, Toronto, ON, Canada Univ London St Georges Hosp, Sch Med, London SW17 0RE, England Univ LondonSt Georges Hosp London England SW17 0RE on SW17 0RE, England Netherhall Gardens, London, England Netherhall Gardens London EnglandNetherhall Gardens, London, England Univm,msterdam, Acad Med Ctr, Dept Clin & Expt Cardiol, NL-1105 AZ Amsterda Univ Amsterdam Amsterdam Netherlands NL-1105 AZ iol, NL-1105 AZ Amsterda Sanofi Rech, F-34082 Montpellier, France Sanofi Rech Montpellier France F-34082 Rech, F-34082 Montpellier, France
Titolo Testata:
CIRCULATION
fascicolo: 17, volume: 99, anno: 1999,
pagine: 2268 - 2275
SICI:
0009-7322(19990504)99:17<2268:AIWB-A>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADRENOCEPTORS; SR-33589;
Keywords:
antiarrhythmia agents; myocardial infarction; trials;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Boissel, JP Servancermacol Clin, EA 643,162 Ave Lacassagne,BP 3041, F-69394 Lyon 03, Fr Serv Pharmacol Clin EA 643,162 Ave Lacassagne,BP 3041 Lyon France 03
Citazione:
F. Boutitie et al., "Amiodarone interaction with beta-blockers - Analysis of the merged EMIAT (European Myocardial Infarct Amiodarone Trial) and CAMIAT (Canadian Amiodarone Myocardial Infarction Trial) databases", CIRCULATION, 99(17), 1999, pp. 2268-2275

Abstract

Background-Investigations with in vitro and animal models suggest an interaction between amiodarone and beta-blockers. The objective of this work wasto explore if an interaction with beta-blocker treatment plays a role in the decrease of cardiac arrhythmic deaths with amiodarone in patients recovered from an acute myocardial infarction. Methods and Results-A pooled database from 2 similar randomized clinical trials, the European Amiodarone Myocardial Infarction Trial (EMIAT) and the Canadian Amiodarone Myocardial Infarction Trial (CAMIAT), was used. Four groups of post-myocardial infarction patients were defined: beta-blockers andamiodarone used, beta-blockers used alone, amiodarone used alone, and neither used. All analyses were done on an intention-to-treat basis. Unadjustedand adjusted relative risks for all-cause mortality, cardiac death, arrhythmic cardiac death, nonarrhythmic cardiac death, arrhythmic death, or resuscitated cardiac arrest were lower for patients receiving beta-blockers and amiodarone than for those without beta-blockers, with or without amiodarone. The interaction was statistically significant fur cardiac death and arrhythmic death or resuscitated cardiac arrest (P=0.05 and 0.03, respectively). Findings were consistent across subgroups. Conclusions-These findings are based on a post hoc analysis. However, theyconfirm prior results from in vitro and animal experiments suggesting an interaction between beta-blockers and amiodarone. In practice, not only is the adjunct of amiodarone to beta-blockers not hazardous, but beta-blocker therapy should be continued if possible in patients in whom amiodarone is indicated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 03:20:10