Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Chirality and drugs used in psychiatry: Nice to know or need to know?
Autore:
Lane, RM; Baker, GB;
Indirizzi:
Pfizer Inc, New York, NY 10017 USA Pfizer Inc New York NY USA 10017Pfizer Inc, New York, NY 10017 USA Univ Alberta, Psychiat Mackenzie Ctr, Neurochem Res Unit Dept, Edmonton, AB Univ Alberta Edmonton AB Canada T6G 2B7 ochem Res Unit Dept, Edmonton, AB
Titolo Testata:
CELLULAR AND MOLECULAR NEUROBIOLOGY
fascicolo: 3, volume: 19, anno: 1999,
pagine: 355 - 372
SICI:
0272-4340(199906)19:3<355:CADUIP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; SEROTONIN REUPTAKE INHIBITORS; RAT-LIVER MICROSOMES; HUMAN-SERUM ALBUMIN; CLINICAL PHARMACOKINETICS; NORFLUOXETINE ENANTIOMERS; PLASMA-LEVELS; CAPILLARY ELECTROPHORESIS; GAS-CHROMATOGRAPHY; ENANTIOSELECTIVE DETERMINATION;
Keywords:
enantiomers; racemic; chiral; stereoselective; pharmacokinetics; cytochrome P450; geometric isomers;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
134
Recensione:
Indirizzi per estratti:
Indirizzo: Lane, RM Pfizer Inc, 235 E 42nd St, New York, NY 10017 USA Pfizer Inc 235 E 42nd St New York NY USA 10017 York, NY 10017 USA
Citazione:
R.M. Lane e G.B. Baker, "Chirality and drugs used in psychiatry: Nice to know or need to know?", CELL MOL N, 19(3), 1999, pp. 355-372

Abstract

1. Many drugs used to treat psychiatric disorders contain a chiral center or a center of unsaturation and are marketed as a mixture of the resultant enantiomers or geometric isomers, respectively. These enantiomers or geometric isomers may differ markedly with regard to their pharmacodynamic and/orpharmacokinetic properties.2. Examples of the effects of chiral centers or geometric centers on such properties are given for drugs from the following classes: antidepressants (tricyclics, selective serotonin reuptake inhibitors, monoamine oxidase inhibitors, viloxazine, bupropion, trazodone, mianserin, venlaflaxine); benzodiazepines, zoplicone, and antipsychotics.3. As described in this review, there are several notable examples of psychiatric drugs currently available where the individual enantiomers or geometric isomers differ considerably with regard to factors such as effects on amine transport systems, interactions with receptors and metabolizing enzymes, and clearance rates from the body. Indeed, relatively recent developments in analytical and preparative resolution of racemic and geometric drug mixtures and increased interest in developing new drugs which interact with specific targets, which have been described in detail at the molecular level, have resulted in increased emphasis on stereochemistry in drug development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 03:33:35