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Titolo:
Cicatricial pemphigoid: serial titres of circulating IgG and IgA antibasement membrane antibodies correlate with disease activity
Autore:
Setterfield, J; Shirlaw, PJ; Bhogal, BS; Tilling, K; Challacombe, JS; Black, MM;
Indirizzi:
St Thomas Hosp, St Johns Inst Dermatol, London SE1 7EH, England St Thomas Hosp London England SE1 7EH Dermatol, London SE1 7EH, England St Thomas Hosp, Dept Publ Hlth Med, London SE1 7EH, England St Thomas Hosp London England SE1 7EH Hlth Med, London SE1 7EH, England Guys Hosp, Dept Oral Med & Pathol, London SE1 9RT, England Guys Hosp London England SE1 9RT l Med & Pathol, London SE1 9RT, England
Titolo Testata:
BRITISH JOURNAL OF DERMATOLOGY
fascicolo: 4, volume: 140, anno: 1999,
pagine: 645 - 650
SICI:
0007-0963(199904)140:4<645:CPSTOC>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOELECTRON MICROSCOPY; SUCCESSFUL THERAPY; BULLOUS DISEASES; AUTOANTIBODIES; IDENTIFICATION; ANTIGENS; TISSUE; IMMUNOFLUORESCENT; TITERS;
Keywords:
autoantibody; basement membrane zone; cicatricial pemphigoid; immunofluorescence;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Setterfield, J St Thomas Hosp, St Johns Inst Dermatol, London SE1 7EH, England St Thomas Hosp London England SE1 7EH on SE1 7EH, England
Citazione:
J. Setterfield et al., "Cicatricial pemphigoid: serial titres of circulating IgG and IgA antibasement membrane antibodies correlate with disease activity", BR J DERM, 140(4), 1999, pp. 645-650

Abstract

We have recently shown in a cohort of patients (n = 67) with mucous membrane pemphigoid, 63 of whom had cicatricial pemphigoid (CP), that the presence of both IgG and IgA circulating antibasement membrane zone antibodies wasassociated with a more severe and persistent disease. In this study we sought to ascertain whether in CP, serial titres of IgG and IgA might provide a reliable marker of disease activity, Serum titres for IgG and IgA antibodies were assayed at 6- to 12-monthly intervals in 56 patients over 32.2 +/-20.3 (mean +/- SD) months. Antibody titres were correlated with the clinical score recorded at each follow-up visit. Sequential titres for both IgG (P < 0.001) and IgA (P = 0.015) were significantly associated with variations in disease activity, Greatest improvement was seen in patients with the greatest change in either IgG or IgA antibody titre. We suggest that serial antibody titres may therefore be useful in the assessment and management ofCP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/08/20 alle ore 19:56:44