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Titolo:
Evaluation of the effects of photodynamic therapy with phosphorus 31 magnetic resonance spectroscopy
Autore:
Nishiwaki, M; Fujise, Y; Yoshida, TO; Matsuzawa, E; Nishiwaki, Y;
Indirizzi:
HamamatsuJapan, Sch Med, Dept Internal Med 2, Hamamatsu, Shizuoka 4313192,Hamamatsu Univ Hamamatsu Shizuoka Japan 4313192 amatsu, Shizuoka 4313192, Hamamatsu192,v, Sch Med, Dept Microbiol & Immunol, Hamamatsu, Shizuoka 4313 Hamamatsu Univ Hamamatsu Shizuoka Japan 4313192 Hamamatsu, Shizuoka 4313 Hamamatsu Univ, Sch Med, Dept Chem, Hamamatsu, Shizuoka 4313192, Japan Hamamatsu Univ Hamamatsu Shizuoka Japan 4313192 , Shizuoka 4313192, Japan Hamamatsu Photon KK, Hamamatsu, Shizuoka, Japan Hamamatsu Photon KK Hamamatsu Shizuoka Japan Hamamatsu, Shizuoka, Japan Hamamatsu Med Ctr, Hamamatsu, Shizuoka 432, Japan Hamamatsu Med Ctr Hamamatsu Shizuoka Japan 432 matsu, Shizuoka 432, Japan
Titolo Testata:
BRITISH JOURNAL OF CANCER
fascicolo: 1-2, volume: 80, anno: 1999,
pagine: 133 - 141
SICI:
0007-0920(199904)80:1-2<133:EOTEOP>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
P-31 NMR-SPECTROSCOPY; R3230AC MAMMARY ADENOCARCINOMAS; MR SPECTROSCOPY; SOLID TUMORS; INVIVO; PHOTOSENSITIZATION; METABOLISM; CARCINOMA; ENZYMES; WORK;
Keywords:
photodynamic therapy (PDT); phosphorus 31 magnetic resonance spectroscopy (P-31 MRS); YAG optical parametric oscillator laser (YAG-OPO laser); ATX-S10; HeLa cell tumour;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Nishiwaki, M Hamamatsuizuoka Sch Med, Dept Internal Med 2, 3600 Handa Cho,Hamamatsu, Sh Hamamatsu Univ 3600 Handa Cho Hamamatsu Shizuoka Japan 4313192
Citazione:
M. Nishiwaki et al., "Evaluation of the effects of photodynamic therapy with phosphorus 31 magnetic resonance spectroscopy", BR J CANC, 80(1-2), 1999, pp. 133-141

Abstract

Magnetic resonance spectroscopy in situ was used to study changes in phosphorus 31 metabolism after photodynamic therapy (PDT) of transplanted HeLa cell tumours. Tumours were irradiated 2 h after administration of ATX-S10 (8-formyloximethylidene-7-hydroxy-3-ethenyl-2,7,12,18, tetramethyl-porphyrin-13,17-bispropionil aspartate), a new photosensitizer and chlorin derivative. Nuclear magnetic resonance spectra were measured prior to illumination and 1, 3, 7, 14, 21 and 28 days after PDT on each mouse. A drastic decrease in adenosine triphosphate (ATP) and a concomitant increase in inorganic phosphate (Pi) were evident on the first day after PDT in all cases. The beta-ATP/total phosphate (P) ratio was 0.64 +/- 0.29% (average +/- s.d.) in complete response, 0.67 +/- 0.30% in recurrence and 2.45 +/- 0.93% in partial response. Comparison of this ratio to the histological findings revealed thatthe beta-ATP/total P ratio reflects the HeLa cell tumours which survived PDT. In other words, partial response on the one hand was distinguished fromcomplete response and recurrence on the other with this ratio 1 day after PDT (P < 0.05). In addition, the ratio of phosphomonoester (PME) to Pi rosebeyond 1.0 when macroscopic recurrence occurred, while it stayed under 1.0in complete response. This finding suggests that the recurrence of HeLa cell tumours can be detected by the PME/Pi ratio.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 18:04:53