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Titolo:
Multiple single units and population responses during inhibitory gating ofhippocampal auditory response in freely-moving rats
Autore:
Moxon, KA; Gerhardt, GA; Bickford, PC; Austin, K; Rose, GM; Woodward, DJ; Adler, LE;
Indirizzi:
Med29oll Penn & Hahnemann Univ, Dept Anat & Neurobiol, Philadelphia, PA 191 Med Coll Penn & Hahnemann Univ Philadelphia PA USA 19129 adelphia, PA 191 Univ Colorado, Hlth Sci Ctr, Dept Psychiat, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 tr, Dept Psychiat, Denver, CO 80262 USA Univ Colorado, Hlth Sci Ctr, Dept Pharmacol, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 r, Dept Pharmacol, Denver, CO 80262 USA UnivAColorado, Hlth Sci Ctr, Neurosci Training Program, Denver, CO 80262 US Univ Colorado Denver CO USA 80262 i Training Program, Denver, CO 80262 US UnivUSAlorado, Hlth Sci Ctr, Rocky Mt Ctr Sensor Technol, Denver, CO 80262Univ Colorado Denver CO USA 80262 Mt Ctr Sensor Technol, Denver, CO 80262 Vet Adm Med Ctr, Denver, CO 80220 USA Vet Adm Med Ctr Denver CO USA 80220Vet Adm Med Ctr, Denver, CO 80220 USA Wakelem,est Univ, Bowman Gray Sch Med, Dept Physiol & Pharmacol, Winston Sa Wake Forest Univ Winston Salem NC USA 27103 ysiol & Pharmacol, Winston Sa
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 825, anno: 1999,
pagine: 75 - 85
SICI:
0006-8993(19990417)825:1-2<75:MSUAPR>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROPHYSIOLOGICAL EVIDENCE; EVOKED RESPONSE; TEMPORAL-LOBE; SCHIZOPHRENIA; NEURONS; ABNORMALITIES; DISSOCIATION; RECEPTORS; SYSTEMS; DEFECT;
Keywords:
auditory-evoked potential; hippocampus; multiple single-neuron recording; auditory cortex; medial septal nucleus; brainstem reticular formation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Moxon, KA Medadelphia,n & Hahnemann Univ, Dept Anat & Neurobiol, 3200 Henry Ave, Phil Med Coll Penn & Hahnemann Univ 3200 Henry Ave Philadelphia PA USA 19129
Citazione:
K.A. Moxon et al., "Multiple single units and population responses during inhibitory gating ofhippocampal auditory response in freely-moving rats", BRAIN RES, 825(1-2), 1999, pp. 75-85

Abstract

Paired clicks were presented to awake, freely-moving rats to examine neuronal activity associated with inhibitory gating of responses to repeated auditory stimuli. The rats had bundles of eight microwires implanted into eachof four different brain areas: CA3 region of the hippocampus, medial septal nucleus, brainstem reticular nucleus, and the auditory cortex. Single-unit recordings from each wire were made while the local auditory-evoked potential was also recorded. The response to a conditioning stimulus was compared to the response to a test stimulus delivered 500 ms later: the ratio of the test response to the conditioning response provided a measure of inhibitory gating. Auditory-evoked potentials were recorded at all sites. Overall,brainstem reticular nucleus neurons showed the greatest gating of local auditory-evoked potentials, while the auditory cortex showed the least. However, except for the auditory cortex, both gating and non-gating of the evoked response were recorded at various times in all brain regions. Gating of the hippocampal response was significantly correlated with gating in the medial septal nucleus and brainstem reticular nucleus, but not the auditory cortex. Single-unit neuron firing in response to the clicks was most pronounced in the brainstem reticular nucleus and the medial septal nucleus, while relatively few neurons responded in the CA3 region of the hippocampus and the auditory cortex. Taken together, these data support the hypothesis that inhibitory gating of the auditory-evoked response originates in the non-lemniscal pathway and not in cortical areas of the rat brain. (C) 1999 Elsevier Science B.V. All rights reserved.

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Documento generato il 19/01/20 alle ore 09:37:04