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Titolo:
Effect of intravenous infusion of an alpha-adrenergic blocking agent on the haemodynamic changes in human masseter muscle induced by cold pressor stimulation
Autore:
Maekawa, K; Kuboki, T; Miyawaki, T; Shimada, M; Yamashita, A; Clark, GT;
Indirizzi:
Okayama Univ, Sch Dent, Dept Fixed Prosthodont, Okayama 7008525, Japan Okayama Univ Okayama Japan 7008525 d Prosthodont, Okayama 7008525, Japan Okayama Univ, Sch Dent, Dept Dent Anesthesiol, Okayama 7008525, Japan Okayama Univ Okayama Japan 7008525 t Anesthesiol, Okayama 7008525, Japan Univngeles,Los Angeles, Sch Dent, Sect Diagnost Sci & Orofacial Pain, Los A Univ Calif Los Angeles Los Angeles CA USA 90095 i & Orofacial Pain, Los A
Titolo Testata:
ARCHIVES OF ORAL BIOLOGY
fascicolo: 4, volume: 44, anno: 1999,
pagine: 319 - 327
SICI:
0003-9969(199904)44:4<319:EOIIOA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYMPATHETIC-NERVE ACTIVITY; PRIMARY FIBROMYALGIA; BLOCKADE; EXERCISE;
Keywords:
cold pressor test; masseter muscle; near-infrared spectroscopy; phentolamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Maekawa, K Okayama7008525,ch Dent, Dept Fixed Prosthodont, 2-5-1 Shikata Cho, Okayama Okayama Univ 2-5-1 Shikata Cho Okayama Japan 7008525 , Okayama
Citazione:
K. Maekawa et al., "Effect of intravenous infusion of an alpha-adrenergic blocking agent on the haemodynamic changes in human masseter muscle induced by cold pressor stimulation", ARCH ORAL B, 44(4), 1999, pp. 319-327

Abstract

This study evaluated the effect of intravenous infusion of a non-selectivealpha-adrenergic blocking agent on masseter muscle haemodynamics induced by 4 degrees C cold presser stimulation (CPS) of the right foot and ankle, which reportedly evokes a rapidly increasing sympathetic nerve activity in human skeletal muscle. Nine healthy non-smoking males (mean age 23.7+/-2.1 year) with no history of chronic muscle pain or migraine participated. The haemoglobin (Hb) concentration in the right masseter was continuously recorded by non-invasive, near-infrared spectroscopy. Heart rate and blood pressure were also recorded. The experiment involved the following sequence: (I) a placebo (physiological saline) with a CPS trial; (2) a 30-sec maximal voluntary clenching (MVC)-only trial; and (3) an alpha-adrenergic blocking agent with a CPS trial. The saline and drug trials each involved continuous recording for 1 min before, 2 min during and 5 min after the CPS, Physiological saline (20 mi) or phentolamine mesylate (20 ml) were infused at the rateof 3 ml/min. This infusion was begun 15 min before baseline recording and participants were not aware which solution (saline or phentolamine) was being infused. For the MVC trial, each participant performed a 30-sec MVC of his jaw-closing muscles followed by a 15-min rest between each trial. The individual Hb data were adjusted so that the baseline at the beginning of theexperiment was equal to zero and all data were normalized as a percentage of the individual's highest absolute Hb change seen after the MVC. The meanbaseline Hb concentrations 1 min before CPS were significantly higher in the alpha-blocker trial (83.6%) than in the placebo saline trial (P < 0.001). The change in mean Hb concentration from baseline during CPS in the alpha-blocker trial was significantly less than in the placebo trial (P = 0.006). Mean heart rate before CPS was also significantly higher in the alpha-blocker trial (85.2 beats/min) than in the placebo trial (69.6 beats:min) (P <0.001). There were no significant differences in the mean systolic and diastolic blood pressures between the placebo and alpha-blocker trials in any time period. The results suggest that non-selective alpha-adrenoceptor blockade increases the blood volume in the masseter muscle. This change might be due to a combination of peripheral vasodilation and an increase in cardiac output. (C) 1999 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 07:14:32