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Titolo:
Intrathecal adenosine - Interactions with spinal clonidine and neostigminein rat models of acute nociception and postoperative hypersensitivity
Autore:
Chiari, AI; Eisenach, JC;
Indirizzi:
Wake Forest Univ, Sch Med, Dept Anesthesiol, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA
Titolo Testata:
ANESTHESIOLOGY
fascicolo: 5, volume: 90, anno: 1999,
pagine: 1413 - 1421
SICI:
0003-3022(199905)90:5<1413:IA-IWS>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL HORN NEURONS; R-PHENYLISOPROPYL-ADENOSINE; DOSE-RESPONSE; SUBSTANCE-P; CEREBROSPINAL-FLUID; EPIDURAL CLONIDINE; PAIN; ANTINOCICEPTION; ANALGESIA; AGONISTS;
Keywords:
adrenergic; allodynia; postoperative pain; purinergic;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Eisenach, JC WakeCForest Univ, Sch Med, Dept Anesthesiol, Med Ctr Blvd, Winston Salem, N Wake Forest Univ Med Ctr Blvd Winston Salem NC USA 27157 m, N
Citazione:
A.I. Chiari e J.C. Eisenach, "Intrathecal adenosine - Interactions with spinal clonidine and neostigminein rat models of acute nociception and postoperative hypersensitivity", ANESTHESIOL, 90(5), 1999, pp. 1413-1421

Abstract

Background: Spinal adenosine receptor agonists exert antinociception in animal models of acute and chronic pain, but adenosine itself has not been examined. The authors tested the antinociceptive and antihypersensitivity interactions of intrathecal adenosine and its interactions with intrathecal clonidine and neostigmine in rat models of acute thermal nociception and postoperative hypersensitivity. Methods: Rats were prepared with lumbar intrathecal catheters. Responses to acute noxious stimulation were evaluated by latency to paw withdrawal from a radiant heat source focused on the hind paw. Postoperative hypersensitivity was measured after an incision in the rat hind paw by application of von Frey filaments to the heel adjacent to the wound. An isobolographic design was used to distinguish between additive and synergistic drug interactions. Results: Spinal administration of clonidine and neostigmine, but not adenosine, produced dose-dependent antinociception to noxious thermal stimulation. Addition of adenosine enhanced the antinociceptive effect of clonidine but not neostigmine. In contrast, each of these three agents alone reversed postoperative hypersensitivity. Pretreatment with the cu-adrenergic antagonist phentolamine completely reversed adenosine's antihypersensitivity action. Adenosine interacted synergistically with neostigmine and additively with clonidine in reducing postoperative hypersensitivity. Conclusions: These data indicate that intrathecal adenosine by itself has no antinociceptive properties to acute noxious thermal stimulation in rats,but enhances clonidine's antinociception. In contrast, intrathecal adenosine is active against postoperative hypersensitivity by an adrenergic mechanism.Different interactions between adenosine, clonidine, and neostigmine inacute nociception and postoperative hypersensitivity models are consistentwith altered central processing of sensory information after peripheral injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:17:37