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Titolo:
COLD STRESS-RELATED ALTERATION OF RNA BIOSYNTHESIS IN BRAIN CORTEX OFMOTHER-DEPRIVED NEWBORN RATS
Autore:
IBARRA GR; PARATCHA GC; RODRIGUEZ JA; NAPP MI; AZCURRA JM;
Indirizzi:
UNIV BUENOS AIRES,FAC CIENCIAS EXACTAS & NAT,LAB BIOL CELULAR,4 PISO,PABELLON 2,CIUDAD UNIV RA-1428 BUENOS AIRES DF ARGENTINA UNIV BUENOS AIRES,FAC CIENCIAS EXACTAS & NAT,LAB BIOL CELULAR RA-1428BUENOS AIRES DF ARGENTINA
Titolo Testata:
Life sciences
fascicolo: 24, volume: 60, anno: 1997,
pagine: 2165 - 2171
SICI:
0024-3205(1997)60:24<2165:CSAORB>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
MATERNAL SEPARATION; AMPHETAMINE; STIMULATION; DEPRIVATION; DEPRESSION; ENDOCRINE; RESPONSES; PUPS;
Keywords:
BRAIN DEVELOPMENT; BRAIN CORTEX; MATERNAL DEPRIVATION; COLD STRESS; RNA BIOSYNTHESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
G.R. Ibarra et al., "COLD STRESS-RELATED ALTERATION OF RNA BIOSYNTHESIS IN BRAIN CORTEX OFMOTHER-DEPRIVED NEWBORN RATS", Life sciences, 60(24), 1997, pp. 2165-2171

Abstract

We studied the influence of maternal deprivation on the RNA biosynthesis in the brain cortex of 10 day-old rats. Mother-deprived pups, placed at 25 degrees C showed a reduction in body temperature of 6 +/- 1 degrees C. After mother retrieval, RNA biosynthesis decreased 27% and 34% in total brain cortex and in isolated neurons, respectively. This fall is proportional to the body temperature reduction and can be avoided placing the pups at 37 degrees C immediately after the separation. Rethermostatization of offsprings, after one hour at 25 degrees C, showed an overshoot of RNA biosynthesis (145%) with further stabilizationof synthesis rates to normal levels after 100 min. This classical physiological mechanism was further studied in vitro. Comparing in vivo and in vitro experiments, it is concluded that overshooting can not be observed in vitro if temperature reduction was not previously performed in vivo. Thus, this phenomenon seems to respond to humoral factors in order to be triggered. Afterwards, in vitro overshooting following cold stress in vivo, demonstrates that the depressed tissue by itself has the capability to turn back to normal RNA levels in the same way asobserved in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:24:54