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Titolo:
Increase of serum des-gamma-carboxy prothrombin in alcoholic liver diseasewithout hepatocellular carcinoma
Autore:
Ohhira, M; Ohtake, T; Saito, H; Ikuta, K; Tanaka, K; Tanabe, H; Kawashima, T; Fujimoto, Y; Naraki, T; Ono, M; Kohgo, Y;
Indirizzi:
Asahikawa Med Coll, Dept Internal Med 3, Asahikawa, Hokkaido 0788510, Japan Asahikawa Med Coll Asahikawa Hokkaido Japan 0788510 kkaido 0788510, Japan
Titolo Testata:
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
fascicolo: 4, volume: 23, anno: 1999, supplemento:, S
pagine: 67S - 70S
SICI:
0145-6008(199904)23:4<67S:IOSDPI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ABNORMAL PROTHROMBIN; VITAMIN-K; IMMUNOREACTIVE PROTHROMBIN; TISSUES; MARKER;
Keywords:
PIVKA-II; benign liver disease; tumor marker; vitamin K; gamma-glutamyl carboxylation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Ohhira, M Asahikawaokkaidoll, Dept Internal Med 3, Nishikagura 4-5-3-11, Asahikawa, H Asahikawa Med Coll Nishikagura 4-5-3-11 Asahikawa Hokkaido Japan 0788510
Citazione:
M. Ohhira et al., "Increase of serum des-gamma-carboxy prothrombin in alcoholic liver diseasewithout hepatocellular carcinoma", ALC CLIN EX, 23(4), 1999, pp. 67S-70S

Abstract

The purpose of this study is to determine serum des-gamma-carboxy prothrombin (DCP) levels in benign liver diseases by a new sensitive method, and todemonstrate the elevation of serum DCP in alcoholic liver disease (ALD) without hepatocellular carcinoma (HCC). Median values of serum DCP were 16.2 mAU/ml (range: 3.2 to 1570 mAU/ml) in ALD and 16.7 mAU/ml (1.2 to 75.4 mAU/ml) in viral liver disease (VLD). Using the cut-off value of 40 mAU/ml as atumor marker for HCC, 21% (11/52) was positive in ALD and 2% (1/57) was positive in VLD (p = 0.0014, Fisher's exact probability test), and 27% (9/33)was positive in alcoholic liver cirrhosis and 3% (1/39) was positive in viral liver cirrhosis (p = 0.0042, Fisher's exact probability test). The positive rate of DCP was significantly (p < 0.001, Spearman's rank correlation test) correlated with the severity of liver disease in ALD. Serum vitamin Klevel was not decreased in cases with ALD. In a demonstrable case, serum DCP was decreased after abstinence and was increased again after the beginning of ethanol intake, suggesting the involvement of ethanol to the elevation of serum DCP in ALD. In conclusion, serum DCP was significantly elevated in ALD, compared with VLD, although the mechanism of the elevation of DCP was not clarified. Ethanol intake may act, in part, on the increase of serumDCP in ALD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:11:08