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Titolo:
EFFECT OF NICOTINE ON THE INTIMAL HYPERPLASIA AFTER ENDOTHELIAL REMOVAL OF THE RABBIT CAROTID-ARTERY
Autore:
HAMASAKI H; SATO J; MASUDA H; TAMAOKI S; ISOTANI E; OBAYASHI S; UDAGAWA T; AZUMA H;
Indirizzi:
TOKYO MED & DENT UNIV,INST MED & DENT ENGN,DEPT MED CHEM,CHIYODA KU,2-3-10 SURUGADAI,KANDA TOKYO 101 JAPAN TOKYO MED & DENT UNIV,INST MED & DENT ENGN,DEPT MED CHEM,CHIYODA KU TOKYO 101 JAPAN TOKYO MED & DENT UNIV,DEPT NEUROSURG,FAC MED TOKYO 101 JAPAN TOKYO MED & DENT UNIV,DEPT OBSTET & GYNECOL,FAC MED TOKYO 101 JAPAN TOKYO MED & DENT UNIV,DEPT ANESTHESIOL,FAC MED TOKYO 101 JAPAN
Titolo Testata:
General pharmacology
fascicolo: 5, volume: 28, anno: 1997,
pagine: 653 - 659
SICI:
0306-3623(1997)28:5<653:EONOTI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHESIS; SMOOTH-MUSCLE CELLS; AORTIC ENDOTHELIUM; VASCULAR WALL; INHIBITION; ATHEROSCLEROSIS; ACCUMULATION; CHOLESTEROL; RELEASE; SMOKING;
Keywords:
INTIMAL HYPERPLASIA; ENDOTHELIAL CELLS; NITRIC OXIDE (NO); L-NMMA; ADMA; ENDOTHELIN-1; CHRONIC NICOTINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
H. Hamasaki et al., "EFFECT OF NICOTINE ON THE INTIMAL HYPERPLASIA AFTER ENDOTHELIAL REMOVAL OF THE RABBIT CAROTID-ARTERY", General pharmacology, 28(5), 1997, pp. 653-659

Abstract

1. The present experiments were designed to investigate the effect oflong term oral nicotine (10mg/200ml/kg/day for 7 weeks) on the intimal hyperplasia after endothelial removal of the rabbit carotid artery. 2. The plasma concentrations of nicotine were determined to be 11.7-12.5ng/ml during the term of administration and corresponded to the plasma levels in human smokers. 3. Six weeks after the endothelial removal, light microscopy revealed a marked intimal hyperplasia. Administration of nicotine tended to accelerate the intimal hyperplasia, which wasestimated by comparing the histological findings, DNA content and wetweight of the vessel wall. 4. Acetylcholine- and A23187-induced endothelium-dependent relaxations were greatly impaired in the hyperplasticartery strips. The impairment of relaxations tended to be acceleratedin the nicotine group. Sodium nitroprusside-induced relaxation was not different between the control and the hyperplastic artery strips andremained unaffected in the nicotine group. 5. The concentrations of endogenous nitric oxide (NO) synthesis inhibitors, N-G-monomethyl-L arginine (L-NMMA) and asymmetrical N-G,N-G-dimethyl L-arginine (ADMA) were significantly more increased in the regenerated endothelial cells compared with those in the control endothelial cells. The concentrationsof L-NMMA and ADMA in the regenerated endothelial cells were significantly increased by as much as 1.3 X 10(-6) and 5.6 X 10(-7)M, respectively, in the nicotine group. 6. Immunoreactive endothelin-1 was significantly increased in the hyperplastic vessel wall (2.4 times that of the control) in 6 weeks. Administration of nicotine tended to increase the level. 7. It seems possible to assume from these results that, although, under the present experimental conditions, nicotine exhibited atendency to accelerate the intimal hyperplasia after endothelial removal, the longer exposure to nicotine or a higher dose of the agent or both would significantly accelerate the intimal hyperplasia through the enhanced impairment of endothelium-derived relaxing factor/NO production, which might be brought about by the enhanced increases in L-NMMAand ADMA concentrations, and the enhanced increase in endothelin-1 inthe vessel wall. (C) 1997 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 02:16:18