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Titolo:
Delivery of diagnostic agents for magnetic resonance imaging
Autore:
Okuhata, Y;
Indirizzi:
Nihon Univ, Sch Med, Dept Radiol, Tokyo 1730032, Japan Nihon Univ Tokyo Japan 1730032 ch Med, Dept Radiol, Tokyo 1730032, Japan
Titolo Testata:
ADVANCED DRUG DELIVERY REVIEWS
fascicolo: 1-3, volume: 37, anno: 1999,
pagine: 121 - 137
SICI:
0169-409X(19990504)37:1-3<121:DODAFM>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPERPARAMAGNETIC IRON-OXIDE; MRI CONTRAST AGENT; LABELED MONOCLONAL-ANTIBODIES; SLOW AXONAL-TRANSPORT; III CLINICAL-TRIAL; BLOOD-POOL AGENT; GD-EOB-DTPA; GADOLINIUM-DTPA; IN-VIVO; MN-DPDP;
Keywords:
diagnosis; contrast enhancement; contrast agent; contrast media; capillary permeability; drug delivery; tissue distribution;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
148
Recensione:
Indirizzi per estratti:
Indirizzo: Okuhata, Y Nihonpaniv, Sch Med, Dept Radiol, Ohyaguchikami Cho 30-1, Tokyo1730032, Ja Nihon Univ Ohyaguchikami Cho 30-1 Tokyo Japan 1730032 0032, Ja
Citazione:
Y. Okuhata, "Delivery of diagnostic agents for magnetic resonance imaging", ADV DRUG DE, 37(1-3), 1999, pp. 121-137

Abstract

A review of contrast agents used for magnetic resonance imaging was made with regard to methods of drug delivery using published literature. Since the clinical approval of Gd-DTPA in 1988, there has been extensive research towards developing organ- and tissue-specific contrast agents. Targeting strategies have consistently improved along with improvements in nuclear medicine imaging, and a broad spectrum of potential agents has accumulated. Liver, blood-pool targeted, and, due to their inherent convenience of delivery,intraorally administered. gastrointestinal agents have been developed or are being developed. For intravenous contrast agents, collective magnetic labels with modifications for some specificities results in the larger-sized agents which can be an obstacle for the agent in accessing the targeted cells. In conclusion, the next step in the development of specific contrast agents for clinical use is to improve non-specific delivery to the extra-capillary space adjacent to targeted cells. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 14:16:28