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Titolo:
Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity
Autore:
Schaeffer, EM; Debnath, J; Yap, G; McVicar, D; Liao, XC; Littman, DR; Sher, A; Varmus, HE; Lenardo, MJ; Schwartzberg, PL;
Indirizzi:
Natl Human Genome Res Inst, NIH, Bethesda, MD 20892 USA Natl Human Genome Res Inst Bethesda MD USA 20892 , Bethesda, MD 20892 USA NCI, NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892NCI, NIH, Bethesda, MD 20892 USA NIAID, NIH, Bethesda, MD 20892 USA NIAID Bethesda MD USA 20892NIAID, NIH, Bethesda, MD 20892 USA Tularik, S San Francisco, CA 94080 USA Tularik S San Francisco CA USA 94080 larik, S San Francisco, CA 94080 USA NYU, Med Ctr, Skirball Inst Biomol Med, New York, NY 10016 USA NYU New York NY USA 10016 kirball Inst Biomol Med, New York, NY 10016 USA
Titolo Testata:
SCIENCE
fascicolo: 5414, volume: 284, anno: 1999,
pagine: 638 - 641
SICI:
0036-8075(19990423)284:5414<638:RFTKRA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYROSINE KINASES; ANTIGEN RECEPTOR; PROTEIN-KINASE; TRANSDUCTION; PHOSPHORYLATION; RESISTANCE; ACTIVATION; FAMILY; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Schwartzberg, PL Natl Human Genome Res Inst, NIH, Bethesda, MD 20892 USA Natl Human Genome Res Inst Bethesda MD USA 20892 892 USA
Citazione:
E.M. Schaeffer et al., "Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity", SCIENCE, 284(5414), 1999, pp. 638-641

Abstract

T cell receptor (TCR) signaling requires activation of Zap-70 and Src family tyrosine kinases, but requirements for other tyrosine kinases are Less clear. Combined deletion in;mice of two Tec kinases, Rlk and Itk, caused marked defects in TCR responses including proliferation, cytokine production, and apoptosis in vitro and adaptive:immune responses to Toxoplasma gondii in vivo. Molecular events immediately downstream from the TCR were intact inrlk(-/-)itk(-/-) cells, but intermediate events including inositol trisphosphate production, calcium mobilization, and mitogen-activated protein kinase activation were impaired, establishing Tec kinases as critical regulators of TCR signaling required for phospholipase C-gamma activation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:23:02