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Titolo:
Localization of interleukin-13 gene-expressing cells in tuberculin reactions and lesional skin from patients with atopic dermatitis
Autore:
van der Ploeg, I; Matuseviciene, G; Fransson, J; Wahlgren, CF; Olsson, T; Scheynius, A;
Indirizzi:
Karolinska Hosp & Inst, Dept Lab Med, Div Clin Immunol, Stockholm, Sweden Karolinska Hosp & Inst Stockholm Sweden Clin Immunol, Stockholm, Sweden Karolinska,Hosp & Inst, Dept Ear & Skin, Div Dermatol & Venereol, Stockholm Karolinska Hosp & Inst Stockholm Sweden Dermatol & Venereol, Stockholm Karolinska Hosp & Inst, Dept Neurol, Mol Med Unit, Stockholm, Sweden Karolinska Hosp & Inst Stockholm Sweden Mol Med Unit, Stockholm, Sweden
Titolo Testata:
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
fascicolo: 4, volume: 49, anno: 1999,
pagine: 447 - 453
SICI:
0300-9475(199904)49:4<447:LOIGCI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN IGE SYNTHESIS; T-CELLS; B-CELLS; ALLERGEN CHALLENGE; INTERFERON-GAMMA; IL-13; CYTOKINE; AEROALLERGEN; PROFILES; ASTHMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: van der Ploeg, I Karolinska Hosp, Div Clin Immunol, Dept Lab Med, S-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-17176 ckholm, Sweden
Citazione:
I. van der Ploeg et al., "Localization of interleukin-13 gene-expressing cells in tuberculin reactions and lesional skin from patients with atopic dermatitis", SC J IMMUN, 49(4), 1999, pp. 447-453

Abstract

Interleukin (IL)-13 is a cytokine thought to play an important role in IgE-mediated allergic reactions, The aims of the present study were to localize IL-13 mRNA in positive tuberculin reactions and atopic dermatitis lesionsusing in situ hybridization and to study the possible influence of atopy on the cytokine gene expression in tuberculin reactions. Punch biopsy specimens were taken from tuberculin reactions in 17 nonatopic and 12 atopic (Phadiatop positive), but otherwise healthy, individuals 72 h after injection of purified protein derivative, from chronic lichenified lesions and nonlesional skin in six patients with atopic dermatitis and from normal skin in 12healthy individuals. IL-13-mRNA-producing cells were located mainly in thedermal-cell infiltrates, both in atopic dermatitis lesions and tuberculin reactions. In the atopic dermatitis lesions, IL-13-mRNA expression was found in close apposition to the epidermis, Higher numbers of IL-13-mRNA-producing cells were observed in the dermal-cell infiltrates of chronic lichenified skin lesions of patients with atopic dermatitis (13.3 cells/mm(2), range0.6-42.4 cells/mm(2)) than in the tuberculin reactions (1.1 cells/mm(2), range 0-3.8 cells/mm(2)) (P < 0.01) despite the larger cell infiltrates in the tuberculin reactions. No significant difference in IL-13 or interferon-gamma gene expression in the tuberculin reactions was seen between atopic and nonatopic individuals.

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Documento generato il 24/11/20 alle ore 08:31:47