Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CHRONIC MYELOMONOCYTIC LEUKEMIA - FROM BIOLOGY TO THERAPY
Autore:
CAMBIER N; BARUCHEL A; SCHLAGETER MH; MENOT ML; WATTEL E; FENAUX P; CHOMIENNE C;
Indirizzi:
HOP ST LOUIS,LAB BIOL CELLULAIRE HEMATOPOIET,1 AVE CLAUDE VELLEFAUX F-75010 PARIS FRANCE HOP ST LOUIS,SERV PEDIAT F-75010 PARIS FRANCE CHU LILLE,SERV MALAD SANG F-59037 LILLE FRANCE
Titolo Testata:
HEMATOLOGY AND CELL THERAPY
fascicolo: 2, volume: 39, anno: 1997,
pagine: 41 - 48
SICI:
1269-3286(1997)39:2<41:CML-FB>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYELOID-LEUKEMIA; GROWTH-FACTOR RECEPTOR; TRANS-RETINOIC ACID; CHRONIC MYELOGENOUS LEUKEMIA; RESISTANCE P-GLYCOPROTEIN; FLUORESCENCE INSITU HYBRIDIZATION; PRIMARY MYELODYSPLASTIC SYNDROMES; ACUTE PROMYELOCYTIC LEUKEMIA; COLONY-STIMULATING FACTOR; RAS GENE-MUTATIONS;
Keywords:
CMML (CHRONIC MYELOMONOCYTIC LEUKEMIA); JCML (JUVENILE CHRONIC MYELOMONOCYTIC LEUKEMIA); RETINOIDS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
115
Recensione:
Indirizzi per estratti:
Citazione:
N. Cambier et al., "CHRONIC MYELOMONOCYTIC LEUKEMIA - FROM BIOLOGY TO THERAPY", HEM CELL TH, 39(2), 1997, pp. 41-48

Abstract

Chronic myelomonocytic leukemia represents a distinct myelodysplasticsyndrome in which an excess of monocytes is observed both in the blood and bone marrow of the patients. Whereas diagnosis is relatively easy, therapeutic design and efficacy is difficult and no treatment has to date provided complete or significant partial response. In vitro data suggest that the growth and differentiation of myelomonocytic progenitors may be altered inasmuch as monocytic or granule-macrophagic colonies show spontaneous growth. Different entities may be observed: the childhood form, Juvenile Chronic Myelomonocytic Leukemia (JCML) shows in vitro a typical pattern with constitutive growth of only macrophagic colonies and hypersensitivity to GM-CSF; in the adult form at least two patterns may be observed one close to the JCML form and one more heterogeneous with absence of GM-CSF sensitivity and spontaneous growthof both CFU-GM and CFU-M colonies. Chemotherapy reduces all myeloid colonies in vitro whereas retinoic acid has a selective effect on monocytic colonies with a concomitant increase of CFU-G colonies forwardingan explanation for the correction of pancytopenia observed in some patients. Recent analysis of altered molecular pathways in this disease suggest a common disruption of intracelleular signalling pathways namely the Ras pathway and targetting for drugs with may selectively control or inhibit a constitutive activation may forward novel therapeutic perspectives.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:31:38