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Titolo:
Cognitive enhancing effects in young and old rats of pBC(264), a selectiveCCKB receptor agonist
Autore:
Taghzouti, K; Lena, I; Dellu, F; Roques, BP; Dauge, V; Simon, H;
Indirizzi:
Univ7Bordeaux 2, INSERM, U259, Lab Psychol Comportements Adaptatifs, F-3307 Univ Bordeaux 2 Bordeaux France F-33077 Comportements Adaptatifs, F-3307 UnivF-7527005, Lab Pharmacochim Mol & Struct, CNRS,URA D1500, INSERM,U266,Univ Paris 05 Paris France F-75270 Struct, CNRS,URA D1500, INSERM,U266, Fac Sci, Physiol Anim Lab, Rabat, Morocco Fac Sci Rabat MoroccoFac Sci, Physiol Anim Lab, Rabat, Morocco
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 2, volume: 143, anno: 1999,
pagine: 141 - 149
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLECYSTOKININ-B RECEPTOR; 2-TRIAL MEMORY TASK; NUCLEUS-ACCUMBENS; OLFACTORY RECOGNITION; PANIC DISORDER; HIGHLY POTENT; BINDING-SITES; BRAIN; ANTAGONISTS; L-365,260;
Keywords:
BC264; cholecystokinin; CCKB receptor; memory; ageing; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Simon, H UniveBordeaux 2, INSERM, U259, Lab Psychol Comportements Adaptatifs, Domain Univ Bordeaux 2 Domaine de Carreire,Rue Camille St Saens Bordeaux France F-33077
Citazione:
K. Taghzouti et al., "Cognitive enhancing effects in young and old rats of pBC(264), a selectiveCCKB receptor agonist", PSYCHOPHAR, 143(2), 1999, pp. 141-149

Abstract

Rationale: The implication of CCKB receptors in cognitive processes is farfrom fully understood. Objective: The present study investigated the effect of propionyl-BC264, a selective agonist of CCKB receptors, in young and old rats. Methods: Cognitive functions were studied in a two-trial recognition memory task developed in our laboratory. Results: It was shown that propionyl-BC264 enhanced information processing in young as well as in old ratswhen injected (10 mu g/kg; IF) immediately after the acquisition phase andbefore the retrieval trial but not before the acquisition trial. This cognitive enhancing effect was blocked by prior administration of L 365,260, a selective CCKB receptor antagonist. Conclusions: In view of the fact that BC264 is devoid of anxiogenic effects, it could be of value in the treatmentof cognitive impairments associated with both normal and pathological ageing.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 08:54:31