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Titolo:
A topographic event-related potential follow-up study on 'prepulse inhibition' in first and second episode patients with schizophrenia
Autore:
Bender, S; Schall, U; Wolstein, J; Grzella, I; Zerbin, D; Oades, RD;
Indirizzi:
Univherapy,Gesamthsch, Biol Psychiat Res Grp, Clin Adult Psychiat & Psychot Univ Essen Gesamthsch Essen Germany D-45147 lin Adult Psychiat & Psychot Univiatsen Gesamthsch, Biol Psychiat Res Grp, Clin Child & Adolescent Psych Univ Essen Gesamthsch Essen Germany D-45147 lin Child & Adolescent Psych
Titolo Testata:
PSYCHIATRY RESEARCH-NEUROIMAGING
fascicolo: 1, volume: 90, anno: 1999,
pagine: 41 - 53
SICI:
0925-4927(19990222)90:1<41:ATEPFS>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSESSIVE-COMPULSIVE DISORDER; ACOUSTIC STARTLE RESPONSE; AUDITORY-DISCRIMINATION; STIMULATION INTERVAL; HEALTHY-SUBJECTS; ANIMAL-MODEL; ATTENTION; DOPAMINE; RATS; ERPS;
Keywords:
sensory gating; Go/NoGo task; attention; P50; N100; P300; positive and negative symptoms;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Bender, S Univ47ssen Gesamthsch, Clin Psychiat & Psychotherapy, Virchowstr174, D-451 Univ Essen Gesamthsch Virchowstr 174 Essen Germany D-45147 -451
Citazione:
S. Bender et al., "A topographic event-related potential follow-up study on 'prepulse inhibition' in first and second episode patients with schizophrenia", PSYCH RES-N, 90(1), 1999, pp. 41-53

Abstract

Dopamine agonists impair and antagonists normalize prepulse inhibition (PPI) of startle and gating of the P50 event-related potential (ERP), but the within-subject effect of treatment on impaired gating in schizophrenia has not been studied. We report the first results of a longitudinal study usingPPI of ERPs as a measure of sensory gating in an auditory Go/NoGo discrimination. After admission and approximately 3 months later, at discharge, 15 patients with schitophrenia performed a discrimination between a 1.4 kHz target tone and an 0.8 kHz non-target tone with no prepulse, or with a prepulse at 100 ms or 500 ms before either tone. ERPs were recorded from 19 sites. Healthy subjects were studied twice, with 3 months between sessions. PPI of the P50 peak in the 100-ms condition was reduced in patients on admission. At discharge, decreased negative symptoms correlated with enhanced PS0-PPI at frontocentral sites. After treatment increased N100-PPI at centrotemporal sites correlated with fewer positive symptoms. At frontal sites in the100-ms condition, the initially small difference of non-target minus target P300 amplitudes increased as negative symptoms decreased. It is concludedthat weak auditory prepulses interfere with early auditory stimulus processing (P50), channel selection (N100) and selective attention (P300). Gatingof these stages of processing is impaired in psychotic patients and treatment tends to normalize gating in tandem with improvements of different types of symptoms. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 15:09:05