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Titolo:
Positive correlation between reduction of handwriting area and D-2 dopamine receptor occupancy during treatment with neuroleptic drugs
Autore:
Kuenstler, U; Juhnhold, U; Knapp, WH; Gertz, HJ;
Indirizzi:
Univ Leipzig, Dept Psychiat, D-04103 Leipzig, Germany Univ Leipzig Leipzig Germany D-04103 Psychiat, D-04103 Leipzig, Germany Univ Leipzig, Dept Nucl Med, D-04103 Leipzig, Germany Univ Leipzig Leipzig Germany D-04103 Nucl Med, D-04103 Leipzig, Germany
Titolo Testata:
PSYCHIATRY RESEARCH-NEUROIMAGING
fascicolo: 1, volume: 90, anno: 1999,
pagine: 31 - 39
SICI:
0925-4927(19990222)90:1<31:PCBROH>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHIZOPHRENIC-PATIENTS; RATING-SCALE; D2 RECEPTORS; CLOZAPINE;
Keywords:
fine extrapyramidal-motor symptoms; single photon emission tomography; haloperidol; clozapine; risperidone; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Kuenstler, U Univ Leipzig, Dept Psychiat, Liebigstr 22, D-04103 Leipzig, Germany Univ Leipzig Liebigstr 22 Leipzig Germany D-04103 g, Germany
Citazione:
U. Kuenstler et al., "Positive correlation between reduction of handwriting area and D-2 dopamine receptor occupancy during treatment with neuroleptic drugs", PSYCH RES-N, 90(1), 1999, pp. 31-39

Abstract

We investigated the relationship between fine extrapyramida-motor symptoms(reduction of hand-writing area) and D-2 dopamine receptor occupancy underneuroleptic treatment. The handwriting of 18 schizophrenic patients beforeand during treatment with typical (haloperidol, haloperidol decanoate) andatypical (clozapine, risperidone) neuroleptic drugs was examined. Data analysis of the handwriting's examination was carried out with a planimetric computer programme. At the time of the second test of handwriting, D-2 receptor occupancy was determined with single photon emission tomography (SPET) using [I-123]iodobenzamide (I-123-IBZM). In all patients, a reduction of handwriting area and a D-2 receptor occupancy were found. The correlation between reduction of handwriting area and D-2 receptor occupancy for typical and atypical neuroleptic drugs was linear and statistically significant (r =0.9; P > 0.001). Our findings point to the possibility that the reduction of handwriting area may be used as a clinical indicator of D-2 receptor occupancy under treatment with neuroleptic drugs. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:19:05