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Titolo:
In vitro antifungal susceptibilities of Candida albicans and other fungal pathogens to polygodial, a sesquiterpene dialdehyde
Autore:
Lee, SH; Lee, JR; Lunde, CS; Kubo, I;
Indirizzi:
Univ720lif Berkeley, Dept Environm Sci Policy & Management, Berkeley, CA 94 Univ Calif Berkeley Berkeley CA USA 94720 y & Management, Berkeley, CA 94
Titolo Testata:
PLANTA MEDICA
fascicolo: 3, volume: 65, anno: 1999,
pagine: 204 - 208
SICI:
0032-0943(199904)65:3<204:IVASOC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMPHOTERICIN-B; PLANTS; MECHANISMS; THREAT; DRUGS;
Keywords:
Polygonaceae; Polygonum hydropiper; Winteraceae; Pseudowintera colorata; polygodial; antifungal; Candida albicans;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Kubo, I Univl,alif Berkeley, Dept Environm Sci Policy & Management, 201 Wellman Hal Univ Calif Berkeley 201 Wellman Hall Berkeley CA USA 94720 man Hal
Citazione:
S.H. Lee et al., "In vitro antifungal susceptibilities of Candida albicans and other fungal pathogens to polygodial, a sesquiterpene dialdehyde", PLANTA MED, 65(3), 1999, pp. 204-208

Abstract

In vitro antifungal activities of polygodial were investigated against several fungal pathogens. Polygodial showed strong antifungal activity, comparable to amphotericin B, against yeast-like fungi Candida albicans, C. utilis, C. krusei. Cryptococcus neoformans. Saccharomyces cerevisiae and also filamentous fungi including Trichophyton mentagrophytes, T. ruburum. and Penicillium marneffei. Other strains such as Aspergillus fumigatus, A. flavus, P. chrysogenum, C. lipolytica, and C. tropicalis showed moderate to low susceptibility to polygodial. The antifungal activity of polygodial was generally not reduced by several susceptibility-testing conditions such as medium, incubation temperature, inoculum size, and medium pH. However, polygodial's antifungal activity was strongly increased at acidic conditions. Unlike amphotericin B, polygodial did not show any hemolytic activity and also itsantifungal activity was not diminished in the presence of ergosterol. Based on killing kinetics against growing and nongrowing C. albicans, polygodial showed strong and rapid fungicidal activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:39:16