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Titolo:
Transgenic mouse models for tumors of melanocytes and retinal pigment epithelium
Autore:
Beermann, F; Hunziker, A; Foletti, A;
Indirizzi:
Swiss Inst Expt Canc Res, ISREC, CH-1066 Epalinges, Switzerland Swiss InstExpt Canc Res Epalinges Switzerland CH-1066 nges, Switzerland
Titolo Testata:
PIGMENT CELL RESEARCH
fascicolo: 2, volume: 12, anno: 1999,
pagine: 71 - 80
SICI:
0893-5785(199904)12:2<71:TMMFTO>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MALIGNANT SKIN MELANOMA; RECEPTOR TYROSINE KINASE; NEURAL CREST DEVELOPMENT; FACTOR SCATTER FACTOR; GROWTH-FACTOR; TRANSFORMING GENE; FUSION GENE; ULTRAVIOLET-RADIATION; CELL-POPULATIONS; T-ANTIGEN;
Keywords:
tyrosinase; TRP-1; ras; SV40 T antigen; ret; RPE; melanoma; metastasis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Beermann, F Swisses,st Expt Canc Res, ISREC, Chemin des Boveresses 155, CH-1066 Epaling Swiss Inst Expt Canc Res Chemin des Boveresses 155 EpalingesSwitzerland CH-1066
Citazione:
F. Beermann et al., "Transgenic mouse models for tumors of melanocytes and retinal pigment epithelium", PIGM CELL R, 12(2), 1999, pp. 71-80

Abstract

Cutaneous and ocular melanomas are due to malignant transformation of neural crest-derived melanocytes. The rising incidence of this tumor in humans has stimulated experiments to devise suitable mouse models. In the past years, transgenic mouse lines have been generated using different oncogenes - Ha-ras, SV40 T antigen (Tag), ret - which develop benign lesions of melanocytes, melanoma, and/or eye tumors. Pigment cell tumors in humans, although rather rare, can also develop from the retinal pigment epithelium (RPE), a cell layer of neuroectodermal origin. We, therefore, established transgenicmodels for this ocular tumor. Regulated by the promoter of tyrosinase-related protein-1 (TRP-1), two oncogenes, ret and SV40 Tag, were targeted to the developing RPE in transgenic mice. The TRP-1/ret transgenic mice displayed microphthalmia and benign tumors of the RPE. Expression of SV40 T antigen(TRP-1/Tag) led to malignant tumors, which were invasive and metastasized to inguinal lymph node and spleen.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:22:01