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Titolo:
Quantitative MRI in CADASIL - Correlation with disability and cognitive performance
Autore:
Dichgans, M; Filippi, M; Bruning, R; Iannucci, G; Berchtenbreiter, C; Minicucci, L; Uttner, I; Crispin, A; Ludwig, H; Gasser, T; Yousry, TA;
Indirizzi:
Univ Munich, Klinikum Grosshadern, Dept Neurol, D-81377 Munich, Germany Univ Munich Munich Germany D-81377 Dept Neurol, D-81377 Munich, Germany Univnyunich, Klinikum Grosshadern, Dept Med Informat, D-81377 Munich, Germa Univ Munich Munich Germany D-81377 t Med Informat, D-81377 Munich, Germa Univ Munich, Klinikum Grosshadern, Dept Biometry, D-81377 Munich, Germany Univ Munich Munich Germany D-81377 ept Biometry, D-81377 Munich, Germany Univ Munich, Klinikum Grosshadern, Dept Epidemiol, D-81377 Munich, GermanyUniv Munich Munich Germany D-81377 pt Epidemiol, D-81377 Munich, Germany UnivyMunich, Klinikum Grosshadern, Dept Neuroradiol, D-81377 Munich, German Univ Munich Munich Germany D-81377 t Neuroradiol, D-81377 Munich, German Univit,lan, Inst Sci, Osped San Raffaele, Dept Neurosci,Neuroimaging Res Un Univ Milan Milan Italy I-20122 ffaele, Dept Neurosci,Neuroimaging Res Un Univrmanych, Klinikum Grosshadern, Inst Diagnost Radiol, D-81377 Munich, Ge Univ Munich Munich Germany D-81377 t Diagnost Radiol, D-81377 Munich, Ge
Titolo Testata:
NEUROLOGY
fascicolo: 7, volume: 52, anno: 1999,
pagine: 1361 - 1367
SICI:
0028-3878(19990422)52:7<1361:QMIC-C>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUTOSOMAL-DOMINANT ARTERIOPATHY; WHITE-MATTER; MULTIPLE-SCLEROSIS; SUBCORTICAL INFARCTS; LEUKOENCEPHALOPATHY CADASIL; PATHOLOGIC CORRELATION; NOTCH3 MUTATIONS; BRAIN MR; DEMENTIA; LESIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Dichgans, M UnivMunich,, Klinikum Grosshadern, Dept Neurol, Marchioninistr15, D-81377 Univ Munich Marchioninistr 15 Munich Germany D-81377 D-81377
Citazione:
M. Dichgans et al., "Quantitative MRI in CADASIL - Correlation with disability and cognitive performance", NEUROLOGY, 52(7), 1999, pp. 1361-1367

Abstract

Objective: To study correlations between total lesion load on brain MRI and clinical features, and to evaluate the influence of demographic variableson quantitative MRI variables in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Background: CADASIL is a hereditary form of small-vessel disease caused by mutations within the Notch3 gene. MRI abnormalities have been found both in asymptomatic and symptomatic CADASIL individuals. Methods: Quantitative measurements on cerebral MRI were performed in 64 CADASIL individuals. MRI lesions were quantified using a semi-automated segmentation technique based on local thresholds. Results: MRI total lesion volume correlated significantly with disability (Rankin Scale) on both T1- and proton density (PD)-weighted images. There was a significant inverse correlation between total lesion volume and overall cognitive performance as determined by the Mini-Mental State Examination. Age but not sex was correlated with lesion load both on T1- and PD-weighted images. There was no detectable influence of the Notch3 genotype on quantitative MRI variables. Conclusions: This study demonstrates correlations between-MRI lesion volume and clinical characteristics in CADASIL. Longitudinal studies are now warranted to investigate whether quantitative MRI could be used as an adjunct outcome measure in future therapeutic trials in CADASIL.

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Documento generato il 09/07/20 alle ore 15:29:27