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Titolo:
Single-locus tests of microsatellite evolution: Multi-step mutations and constraints on allele size
Autore:
Nielsen, R; Palsboll, PJ;
Indirizzi:
Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA Univ CalifBerkeley Berkeley CA USA 94720 at Biol, Berkeley, CA 94720 USA Univ Calif Irvine, Dept Ecol & Evolutionary Biol, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 utionary Biol, Irvine, CA 92697 USA Univ Copenhagen, Dept Populat Biol, DK-2100 Copenhagen, Denmark Univ Copenhagen Copenhagen Denmark DK-2100 , DK-2100 Copenhagen, Denmark
Titolo Testata:
MOLECULAR PHYLOGENETICS AND EVOLUTION
fascicolo: 3, volume: 11, anno: 1999,
pagine: 477 - 484
SICI:
1055-7903(199904)11:3<477:STOMEM>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENETIC DISTANCES; RANGE CONSTRAINTS; NORTH-ATLANTIC; TANDEM REPEATS; FREQUENCIES; DNA; POPULATIONS; WHALES; MITOCHONDRIAL; CHIMPANZEES;
Keywords:
microsatellite evolution; multi-step mutations; constraints on allele size; stepwise mutation model;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Nielsen, R HarvardAve,v, Dept Organism & Evolutionary Biol, Biol Labs 288,16 Divinty Harvard Univ 16 Divinty Ave Cambridge MA USA 02138 , 16 Divinty
Citazione:
R. Nielsen e P.J. Palsboll, "Single-locus tests of microsatellite evolution: Multi-step mutations and constraints on allele size", MOL PHYL EV, 11(3), 1999, pp. 477-484

Abstract

We evaluate some common simulation procedures as well as a recently developed likelihood method used for testing hypotheses regarding microsatellite evolution. Results from simulated data revealed that the tests for the detection of multi-step mutations in general have some power, whereas tests forthe presence of constraints on the repeat number have only very limited power. The tests were applied to population data obtained from nine differentbaleen whale populations. High agreement was found between results obtained using the simulation-based approach and results obtained using a likelihood ratio test. In four of the nine population samples the tests rejected the one-step mutation model. In two instances the significant deviation was due to excess of heterozygosity and in two instances to a reduced level of heterozygosity relative to the expectations under the stepwise mutation model. The former significant deviation was consistent with occasional multi-step mutations, whereas the latter may indicate the presence of constraints on the number of repeat. (C) 1999 Academic Press.

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Documento generato il 25/09/20 alle ore 12:47:48