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Titolo:
"ASCUS, rule out HSIL": Cytologic features, histologic correlates, and human papillomavirus detection
Autore:
Sherman, ME; Tabbara, SO; Scott, DR; Kurman, RJ; Glass, AG; Manos, MM; Burk, RD; Rush, BB; Schiffman, M;
Indirizzi:
NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA NCI BethesdaMD USA 20892 Epidemiol & Genet, NIH, Bethesda, MD 20892 USA Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA Johns HopkinsMed Inst Baltimore MD USA 21205 ol, Baltimore, MD 21205 USA Johns Hopkins Med Inst, Dept Obstet & Gynecol, Baltimore, MD 21205 USA Johns Hopkins Med Inst Baltimore MD USA 21205 ol, Baltimore, MD 21205 USA George Washington Univ, Med Ctr, Dept Pathol, Washington, DC 20037 USA George Washington Univ Washington DC USA 20037 , Washington, DC 20037 USA Kaiser Permanente, Portland, OR USA Kaiser Permanente Portland OR USAKaiser Permanente, Portland, OR USA No Calif Permanente Med Grp, Div Res, Oakland, CA USA No Calif Permanente Med Grp Oakland CA USA Grp, Div Res, Oakland, CA USA Albert Einstein Coll Med, Bronx, NY 10467 USA Albert Einstein Coll Med Bronx NY USA 10467 Coll Med, Bronx, NY 10467 USA
Titolo Testata:
MODERN PATHOLOGY
fascicolo: 4, volume: 12, anno: 1999,
pagine: 335 - 342
SICI:
0893-3952(199904)12:4<335:"ROHCF>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATYPICAL SQUAMOUS CELLS; CERVICAL INTRAEPITHELIAL NEOPLASIA; NEGATIVE PAPANICOLAOU SMEARS; UNDETERMINED SIGNIFICANCE; QUALITY ASSURANCE; RAPID PROGRESSION; RISK; INFECTION; LESIONS; DIAGNOSES;
Keywords:
ASCUS; Bethesda system; atypical squamous cells; cervix; papillomavirus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Sherman, ME NCI,lvd,MSCnc Epidemiol & Genet, NIH, Execut Plaza N,Room 443,6130 Execut B NCI Execut Plaza N,Room 443,6130 Execut Blvd,MSC 7374 Bethesda MD USA 20892
Citazione:
M.E. Sherman et al., ""ASCUS, rule out HSIL": Cytologic features, histologic correlates, and human papillomavirus detection", MOD PATHOL, 12(4), 1999, pp. 335-342

Abstract

Risk factors, cytologic and histopathologic features, and human papillomavirus (HPV) detection associated with 75 cervical smears classified as atypical squamous cells of undetermined significance, rule out high-grade squamous intraepithelial lesion (ASCUS, rule out HSIL) were reviewed, Cases were identified in a pathology panel review of material collected from 1953 women participating in a 5-year prospective study of HPV infection and squamousintraepithelial lesions at Kaiser Permanente, Portland, Oregon, sponsored by the National Cancer Institute. Initial abnormal smears diagnosed as ASCUS, rule out HSIL by one panelist or diagnosed as ASCUS by one pathologist and as HSIL by another were included. The 75 ASCUS, rule out HSIL smears identified were examined again by two pathologists after the study. These cases were compared with cases of ASCUS, not otherwise specified (ASCUS, NOS) and HSIL identified in the same group of 1953 women. Findings in ASCUS, ruleout HSIL included tissue fragments (21%); atypical immature metaplasia (17%); atypical mature metaplasia (15%); small atypical cells (9%); and atypical repair (4%). A final patient classification of HSIL, reflecting all available data, was assigned to 11 (24%) of 46 women with ASCUS, rule out HSIL and to 1(1%) of 80 women with ASCUS, NOS in the original review (P < .001). Detection of oncogenic HPV types at diagnosis in ASCUS, rule out HSIL; ASCUS, NOS; and HSIL was similar, but data were unavailable for many subjects. Among women not tested at diagnosis, enrollment testing (1 to 4 years earlier) revealed that HPV detection in women with ASCUS, rule out HSIL was intermediate in frequency between ASCUS, NOS and HSIL. These data suggest thatASCUS, rule out HSIL is a distinct diagnosis from ASCUS, NOS because it ismore often associated with an underlying HSIL. Consequently, women with ASCUS, rule out HSIL should be referred for colposcopic examination.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 07:12:54