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Titolo:
Prophylaxis of local vascular graft infection with levofloxacin incorporated into albumin-sealed Dacron graft (LVFX-ALB graft)
Autore:
Osada, T; Yamamura, K; Fujimoto, K; Mizuno, K; Sakurai, T; Ohta, M; Nabeshima, T;
Indirizzi:
Nagoyaoya,v, Sch Med, Dept Neuropsychopharmacol & Hosp Pharm, Showa Ku, Nag Nagoya Univ Nagoya Aichi Japan 4668550 rmacol & Hosp Pharm, Showa Ku, Nag Nagoya Univ, Sch Med, Dept Surg 1, Showa Ku, Nagoya, Aichi 4668550, Japan Nagoya Univ Nagoya Aichi Japan 4668550 a Ku, Nagoya, Aichi 4668550, Japan NagoyanUniv, Sch Med, Dept Bacteriol, Showa Ku, Nagoya, Aichi 4668550, Japa Nagoya Univ Nagoya Aichi Japan 4668550 wa Ku, Nagoya, Aichi 4668550, Japa
Titolo Testata:
MICROBIOLOGY AND IMMUNOLOGY
fascicolo: 4, volume: 43, anno: 1999,
pagine: 317 - 321
SICI:
0385-5600(1999)43:4<317:POLVGI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROSTHESES;
Keywords:
graft infection; albumin-sealed Dacron graft; levofloxacin; fluorescent antibody method;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Osada, T NagoyaTsurumaSch Med, Dept Neuropsychopharmacol & Hosp Pharm, Showa Ku, 65 Nagoya Univ 65 Tsuruma Cho Nagoya Aichi Japan 4668550 howa Ku, 65
Citazione:
T. Osada et al., "Prophylaxis of local vascular graft infection with levofloxacin incorporated into albumin-sealed Dacron graft (LVFX-ALB graft)", MICROB IMMU, 43(4), 1999, pp. 317-321

Abstract

An animal model was used to assess the efficacy of levofloxacin (LVFX) incorporated into albumin (ALB)-sealed Dacron (LVFX-ALB) graft for the prevention of vascular graft infections caused by Staphylococcus nul ens. Under general anesthetic, an interposition graft was placed into dog carotid artery. On completion of the operation, 0.1 ml of normal saline containing 10(7) colony- forming units (CFU) of a slime-producing S. aureus was inoculated directly onto the graft. After 1 day, the samples were sterilely harvested. The antibacterial activity of LVFX into the LVFX-ALB graft was evaluated bycolony counting in bacterial cultures and by the fluorescent antibody method staining bacteria adhesion to the grafts. LVFX-ALB grafts had a lower infection rate than the control grafts (1/4, 10(2) CFU vs 4/4, 1.50X10(5)+/-1.38X10(5) CFU (mean+/-SE)). In an immunostaining study, LVFX-ALB grafts hadsmall fluorescent areas showing S. aureus adhesion, while fluorescence wasobserved over the entire surface of the control grafts. Therefore, LVFX-ALB presumably had a bactericidal action and adhesive prevention against inoculated S, aureus. LVFX-ALB may be useful in preventing graft infections during and immediately after vascular reconstruction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/21 alle ore 04:26:29