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Titolo:
Vascular endothelial growth factor (VEGF): Therapeutic angiogenesis and vasculogenesis in the treatment of cardiovascular disease
Autore:
Kalka, C; Takahashi, T; Masuda, H; Asahara, T; Isner, JM;
Indirizzi:
Tufts Univ, Sch Med, St Elizabeths Med Ctr, Dept Vasc Med, Boston, MA 02135 Tufts Univ Boston MA USA 02135 s Med Ctr, Dept Vasc Med, Boston, MA 02135
Titolo Testata:
MEDIZINISCHE KLINIK
fascicolo: 4, volume: 94, anno: 1999,
pagine: 193 - 201
SICI:
0723-5003(19990415)94:4<193:VEGF(T>2.0.ZU;2-7
Fonte:
ISI
Lingua:
GER
Soggetto:
RECEPTOR TYROSINE KINASE; INTRAMUSCULAR GENE-TRANSFER; PERIPHERAL ARTERY DISEASE; EMBRYONIC STEM-CELLS; IN-VITRO; PERMEABILITY FACTOR; COLLATERAL DEVELOPMENT; TUMOR ANGIOGENESIS; LIMB ISCHEMIA; BINDING;
Keywords:
angiogenesis; vasculogenesis; VEGF; gene transfer; endothelial progenitor cell;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
88
Recensione:
Indirizzi per estratti:
Indirizzo: Kalka, C Tufts,Univ, Sch Med, St Elizabeths Med Ctr, Dept Vasc Med, 736 Cambridge St Tufts Univ 736 Cambridge St Boston MA USA 02135 736 Cambridge St
Citazione:
C. Kalka et al., "Vascular endothelial growth factor (VEGF): Therapeutic angiogenesis and vasculogenesis in the treatment of cardiovascular disease", MED KLIN, 94(4), 1999, pp. 193-201

Abstract

The formation of new blood vessel is essential for a variety of physiological processes like embryogenesis and the female reproduction as well as pathological processes like tumor growth, wound healing and neovascularizationof ischemic tissue. Vasculogenesis and angiogenesis are the mechanisms responsible for the development of the blood vessels. While angiogenesis refers to the formation of capillaries from pre-existing vessels in the embryo and adult organism, vasculogenesis, the development of new blood vessels from in situ differentiating endothelial cells, has been previously consideredrestricted to embryogenesis. Recent investigations, however, show the existence of endothelial progenitor cells (EPCs) in the peripheral blood of theadult and their participation in ongoing neovascularization. Molecular andcell-biological experiments suggest that different cytokines and growth factors have a stimulatory effect on these bone-marrow derived EPCs. Results with GM-CSF (granulocyte macrophage-colony stimulating factor) andVEGF (vascular endothelial growth factor) open a new insight into the clinical use of cytokines and in particular the use of growth factors in gene therapy. The administration via protein or plasmid-DNA for neovascularization seems to enhance both pathways, angiogenesis and vasculogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 14:10:21