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Titolo:
5-hydroxytryptamine inhibits the tachycardia induced by selective preganglionic sympathetic stimulation in pithed rats
Autore:
Villalon, CM; Centurion, D; Fernandez, MD; Moran, A; Sanchez-Lopez, A;
Indirizzi:
CINVESTAV, IPN, Mexico City 14000, DF, Mexico CINVESTAV Mexico City DF Mexico 14000 IPN, Mexico City 14000, DF, Mexico Univ Salamanca, Fac Farm, E-37007 Salamanca, Spain Univ Salamanca Salamanca Spain E-37007 ac Farm, E-37007 Salamanca, Spain
Titolo Testata:
LIFE SCIENCES
fascicolo: 20, volume: 64, anno: 1999,
pagine: 1839 - 1847
SICI:
0024-3205(19990409)64:20<1839:5ITTIB>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTORS MEDIATING INHIBITION; CAROTID BLOOD-FLOW; NORADRENALINE RELEASE; 5-HT1-LIKE RECEPTOR; VENA-CAVA; SEROTONIN; 5-HT1B; RESPONSES; SUBTYPES; INCREASE;
Keywords:
5-hydroxytryptamine; prejunctional inhibition; sympathetic outflow; tachycardia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Villalon, CM CINVESTAV, IPN, Apdo Postal 22026, Mexico City 14000, DF, Mexico CINVESTAV Apdo Postal 22026 Mexico City DF Mexico 14000 exico
Citazione:
C.M. Villalon et al., "5-hydroxytryptamine inhibits the tachycardia induced by selective preganglionic sympathetic stimulation in pithed rats", LIFE SCI, 64(20), 1999, pp. 1839-1847

Abstract

It has been shown in several species that serotonin (5-hydroxytryptamine; 5-HT) is able to inhibit the responses produced by sympathetic stimulation in a wide variety of blood vessels and other organs, including the heart. However, in pithed rats, the analysis of potential sympatho-inhibitory actions of 5-HT is hampered by the fact that 5-HT (given as i.v, bolus injections) produces tachycardia per se. Moreover, most studies have investigated 5-HT-induced sympatho-inhibition at only one frequency of stimulation. Thus, the present study set out to find the experimental conditions to overcome these problems. In this regard, we analyzed the potential ability of 5-HT, administered as i.v. continuous infusions, to inhibit the tachycardia causedby stimulation of the preganglionic (C-7-T-1) sympathetic outflow in pithed rats. Sympathetic cardiostimulation (0.01-3 Hz) resulted in frequency-dependent increases in heart rate; these responses were potentiated after desipramine (50 mu g/kg, i.v.). During continuous infusions of 5-HT (3.1-10 mu g/kg.min, i.v.), but not saline, the sympathetically-induced tachycardia was dose-dependently inhibited in both control and desipramine-pretreated rats. This inhibitory effect of 5-HT was significantly more pronounced at lower frequencies of stimulation. In contrast, the above infusions of 5-HT did not inhibit the tachycardia induced by i.v. bolus injections of noradrenaline in both control and desipramine-pretreated rats. Taken together, the above findings confirm that 5-HT induces inhibition of the sympathetic chronotropic outflow in the rat by acting at receptors located prejunctionally, without evoking tachycardia, over a wide range of stimulation frequencies.

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Documento generato il 23/09/20 alle ore 12:59:45