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Titolo:
Hippocampal EEG and unit activity responses to modulation of serotonergic median raphe neurons in the freely behaving rat
Autore:
Nitz, DA; McNaughton, BL;
Indirizzi:
Univ85724ona, Arizona Res Labs, Div Neural Syst Memory & Aging, Tucson, AZUniv Arizona Tucson AZ USA 85724 v Neural Syst Memory & Aging, Tucson, AZ
Titolo Testata:
LEARNING & MEMORY
fascicolo: 2, volume: 6, anno: 1999,
pagine: 153 - 167
SICI:
1072-0502(199903/04)6:2<153:HEAUAR>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
EYE-MOVEMENT SLEEP; THETA-RHYTHM; INHIBITORY INTERNEURONS; AUTORADIOGRAPHIC ANALYSIS; REVERSIBLE INACTIVATION; ASCENDING PROJECTIONS; 5-HT1B AGONISTS; NUCLEUS; DORSAL; 8-OH-DPAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Nitz, DA Univ85724ona, Arizona Res Labs, Div Neural Syst Memory & Aging, Tucson, AZ Univ Arizona Tucson AZ USA 85724 Syst Memory & Aging, Tucson, AZ
Citazione:
D.A. Nitz e B.L. McNaughton, "Hippocampal EEG and unit activity responses to modulation of serotonergic median raphe neurons in the freely behaving rat", LEARN MEM, 6(2), 1999, pp. 153-167

Abstract

Hippocampal EEG, GABAergic interneurons, and principal cells were recordedsimultaneously as rats foraged within one of three environments both before and after modulation of serotonergic inputs to the hippocampus, Median raphe microinjections of the 5-HT1a receptor agonist 8-OH-DPAT were made to produce inhibition of serotonergic neurons in this region, Such microinjections produced behavioral arousal and increases in the amplitude of hippocampal EEG theta. Consistent with the pattern of serotonergic Innervation of the hippocampus, the GABAergic interneuron population was affected differentially by the microinjections. Principal cells were generally unaffected by the manipulation and maintained robust spatial firing correlates within the foraging environment, The results provide basic data on the relationship between serotonergic median raphe neurons and hippocampal activity in a behaving animal. The data suggest that behavioral responses to manipulation of the serotonergic system are mediated. by brain regions other than the hippocampus or are mediated through changes in the activity of hippocampal interneurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 02:48:02