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Titolo:
Memory consolidation for contextual and auditory fear conditioning is dependent on protein synthesis, PKA, and MAP kinase
Autore:
Schafe, GE; Nadel, NV; Sullivan, GM; Harris, A; LeDoux, JE;
Indirizzi:
NYU, Ctr Neural Sci, WM Keck Fdn Lab Neurobiol, New York, NY 10003 USA NYU New York NY USA 10003 Keck Fdn Lab Neurobiol, New York, NY 10003 USA
Titolo Testata:
LEARNING & MEMORY
fascicolo: 2, volume: 6, anno: 1999,
pagine: 97 - 110
SICI:
1072-0502(199903/04)6:2<97:MCFCAA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM-MEMORY; APLYSIA SENSORY NEURONS; ELEMENT-BINDING PROTEIN; CAMP-RESPONSIVE ELEMENT; MEDIAL GENICULATE-BODY; MACROMOLECULAR-SYNTHESIS; SYNAPTIC TRANSMISSION; LASTING POTENTIATION; GENE-EXPRESSION; LATERAL NUCLEUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: LeDoux, JE NYU, Ctr Neural Sci, WM Keck Fdn Lab Neurobiol, New York, NY 10003 USA NYU New York NY USA 10003 ab Neurobiol, New York, NY 10003 USA
Citazione:
G.E. Schafe et al., "Memory consolidation for contextual and auditory fear conditioning is dependent on protein synthesis, PKA, and MAP kinase", LEARN MEM, 6(2), 1999, pp. 97-110

Abstract

Fear conditioning has received extensive experimental attention. However, Little is known about the molecular mechanisms that underlie fear memory consolidation. Previous studies have shown that long-term potentiation (LTP) exists in pathways known to be relevant to fear conditioning and that fear conditioning modifies neural processing in these pathways in a manner similar to LTP induction. The present experiments examined whether inhibition ofprotein synthesis, PKA, and MAP kinase activity, treatments that block LTP, also interfere with the consolidation of fear conditioning. Rats were injected intraventricularly with Anisomycin (100 or 300 mu g), Rp-cAMPS (90 or180 mu g), or PD098059 (1 or 3 mu g) prior to conditioning and assessed for retention of contextual and auditory fear memory both within an hour and 24 hr later. Results indicated that injection of these compounds selectively interfered with long-term memory for contextual and auditory fear, while leaving short-term memory intact. Additional control groups indicated that this effect was Likely due to impaired memory consolidation rather than to nonspecific effects of the drugs on fear expression. Results suggest that fear conditioning and LTP may share common molecular mechanisms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 13:08:19