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Titolo:
A mitogen-activated protein kinase cascade in the CA1/CA2 subfield of the dorsal hippocampus is essential for long-term spatial memory
Autore:
Blum, S; Moore, AN; Adams, F; Dash, PK;
Indirizzi:
Univ&Texas, Sch Med, Dept Neurobiol & Anat, WM Keck Ctr Neurobiol LearningUniv Texas Houston TX USA 77030 ol & Anat, WM Keck Ctr Neurobiol Learning
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 9, volume: 19, anno: 1999,
pagine: 3535 - 3544
SICI:
0270-6474(19990501)19:9<3535:AMPKCI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELEMENT-BINDING PROTEIN; SYNAPTIC PLASTICITY; GENE-EXPRESSION; FACTOR CREB; MAP KINASE; POTENTIATION; PHOSPHORYLATION; IMPAIRMENT; LESIONS; RATS;
Keywords:
MAPK; hippocampus; Morris water maze; long-term memory; PD098059; p38MAPK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Dash, PK Univ&Texas, Sch Med, Dept Neurobiol & Anat, WM Keck Ctr NeurobiolLearning Univ Texas Houston TX USA 77030 , WM Keck Ctr Neurobiol Learning
Citazione:
S. Blum et al., "A mitogen-activated protein kinase cascade in the CA1/CA2 subfield of the dorsal hippocampus is essential for long-term spatial memory", J NEUROSC, 19(9), 1999, pp. 3535-3544

Abstract

Behavioral, biophysical, and pharmacological studies have implicated the hippocampus in the formation and storage of spatial memory. However, the molecular mechanisms underlying long-term spatial memory are poorly understood. In this study, we show that mitogen-activated protein kinase (MAPK, also called ERK) is activated in the dorsal, but not the ventral, hippocampus ofrats after training in a spatial memory task, the Morris water maze. The activation was expressed as enhanced phosphorylation of MAPK in the pyramidal neurons of the CA1/CA2 subfield. In contrast, no increase in the percentage of phospho-MAPK-positive cells was detected in either the CA3 subfield or the dentate gyrus. The enhanced phosphorylation was observed only after multiple training trials but not after a single trial or after multiple trials in which the location of the target platform was randomly changed between each trial. Inhibition of the MAPK/ERK cascade in dorsal hippocampi did not impair acquisition, but blocked the formation of long-term spatial memory. In contrast, intrahippocampal infusion of SB203580, a specific inhibitorof the stress-activated MAPK (p38 MAPK), did not interfere with memory storage. These results demonstrate a MAPK-mediated cellular event in the CA1/CA2 subfields of the dorsal hippocampus that is critical for long-term spatial memory.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 23:20:35