Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Electrotonic coupling interacts with intrinsic properties to generate synchronized activity in cerebellar networks of inhibitory interneurons
Autore:
Mann-Metzer, P; Yarom, Y;
Indirizzi:
Hebrewsrael Jerusalem, Dept Neurobiol, Inst Life Sci, IL-91904 Jerusalem, I Hebrew Univ Jerusalem Jerusalem Israel IL-91904 i, IL-91904 Jerusalem, I Hebrew Univ Jerusalem, Ctr Neural Computat, IL-91904 Jerusalem, Israel Hebrew Univ Jerusalem Jerusalem Israel IL-91904 -91904 Jerusalem, Israel
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 9, volume: 19, anno: 1999,
pagine: 3298 - 3306
SICI:
0270-6474(19990501)19:9<3298:ECIWIP>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIPPOCAMPUS IN-VITRO; SYNAPTIC INHIBITION; STELLATE CELLS; RAT; NEURONS; NUCLEUS; SLICES; MODEL; OSCILLATIONS; SYNAPSES;
Keywords:
cerebellum; electrotonic coupling; synchronization; inhibitory network; inhibitory interneurons; dye coupling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Yarom, Y Hebrewerusalem,usalem, Dept Neurobiol, Inst Life Sci, Givat Ram, IL-91904 J Hebrew Univ Jerusalem Givat Ram Jerusalem Israel IL-91904 1904 J
Citazione:
P. Mann-Metzer e Y. Yarom, "Electrotonic coupling interacts with intrinsic properties to generate synchronized activity in cerebellar networks of inhibitory interneurons", J NEUROSC, 19(9), 1999, pp. 3298-3306

Abstract

Exploring the organization and function of local inhibitory networks is anessential step on the way to understand the principles of brain operation. We show here that molecular layer inhibitory interneurons of the guinea pig cerebellar cortex are organized as local networks, generating synchronousactivity. Simultaneous recording from two adjacent interneurons revealed adirect current flow between synchronized pairs of neurons. Blocking inhibitory or excitatory synaptic transmission did not alter the synchronization. The electrotonic coupling coefficient (average 0.1) depended mainly on theinput resistance of the postsynaptic cell, indicating a homogenous coupling resistance between different pairs. A presynaptic action potential generated a short, attenuated spikelet in the postsynaptic cell. The passive current flow was amplified by voltage-dependent intrinsic currents to create a reciprocal interplay between the presynaptic and postsynaptic cells. This interplay results in a time window for synchronization that is wider than expected from the duration of the spikelet. Intracellular staining with biocytin revealed high incidence of dye coupling. Furthermore, the interneurons located superficially in the molecular layer tend to form larger networks compared with the inner interneurons. We propose that weakly coupled inhibitory networks can generate loosely synchronous activity, which results from the interaction of electrical coupling and intrinsic currents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:25:06