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Titolo:
Effect of radiotherapy on brain glucose metabolism in patients operated onfor low grade astrocytoma
Autore:
Bruehlmeier, M; Roelcke, U; Amsler, B; Schubert, KH; Hausmann, O; von Ammon, K; Radu, EW; Gratzl, O; Landmann, C; Leenders, KL;
Indirizzi:
Paul Scherrer Inst, PET Program, CH-5232 Villigen, Switzerland Paul Scherrer Inst Villigen Switzerland CH-5232 32 Villigen, Switzerland Univ Basel Hosp, Dept Radiotherapy, CH-4031 Basel, Switzerland Univ Basel Hosp Basel Switzerland CH-4031 py, CH-4031 Basel, Switzerland Univ Basel Hosp, Dept Neurosurg, CH-4031 Basel, Switzerland Univ Basel Hosp Basel Switzerland CH-4031 rg, CH-4031 Basel, Switzerland Univ Basel Hosp, Dept Neuroradiol, CH-4031 Basel, Switzerland Univ Basel Hosp Basel Switzerland CH-4031 ol, CH-4031 Basel, Switzerland Univ Zurich Hosp, Dept Neurol, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland Univ Zurich Hosp, Dept Neurosurg, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland
Titolo Testata:
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
fascicolo: 5, volume: 66, anno: 1999,
pagine: 648 - 653
SICI:
0022-3050(199905)66:5<648:EOROBG>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
COGNITIVE FUNCTIONS; RADIATION-THERAPY; C-11 DEOXYGLUCOSE; SEQUELAE; GLIOMAS; IRRADIATION; QUALITY; ADULTS; CANCER; TRIAL;
Keywords:
low grade astrocytoma; brain glucose metabolism; radiotherapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Bruehlmeier, M Paul Scherrer Inst, PET Program, CH-5232 Villigen, Switzerland Paul Scherrer Inst Villigen Switzerland CH-5232 itzerland
Citazione:
M. Bruehlmeier et al., "Effect of radiotherapy on brain glucose metabolism in patients operated onfor low grade astrocytoma", J NE NE PSY, 66(5), 1999, pp. 648-653

Abstract

Objective-To assess the effect of postoperative radiotherapy on brain glucose metabolism (CMRGlu) of operated patients with low grade astrocytomas. Methods-PET and F-18-fluorodeoxyglucose was used to measure absolute CMR-Glu in patients with fibrillary astrocytoma (WHO II) of the frontal lobe, who did (n=7) or did not (n=12) receive radiotherapy subsequent to first debulking tumour resection. In addition, statistical parametric mapping (SPM95)was applied to assess the pattern of relative CMRGlu associated with the frontal tumour. Data were compared with 12 healthy controls. Results-A global reduction of absolute CMRGlu was found when either patients with or without radiotherapy were compared with controls (ROI analysis). Brain areas of relative CMRGlu reduction were found in the brain ipsilateral and contralateral to the tumour, comparing both patient groups with controls by SPM ("tumour diaschisis effect"). Superimposed, absolute CMRGlu in the contralateral frontal, parietal, occipital cortex as well as in the white matter was on average 17% lower in patients receiving radiotherapy than in patients who did not. Conclusions-The data discriminate a tumour effect from a radiotherapy effect, and support the view of adverse effects of radiotherapy on brain not directly involved by tumour.

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Documento generato il 21/01/20 alle ore 01:01:16