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Titolo:
Striatal reconstruction by striatal grafts
Autore:
Dunnett, SB;
Indirizzi:
Univ Cambridge, MRC, Cambridge Ctr Brain Repair, Cambridge CB2 2PY, England Univ Cambridge Cambridge England CB2 2PY air, Cambridge CB2 2PY, England
Titolo Testata:
JOURNAL OF NEURAL TRANSMISSION-SUPPLEMENT
fascicolo: 55, , anno: 1999,
pagine: 115 - 129
SICI:
0303-6995(1999):55<115:SRBSG>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACID-LESIONED STRIATUM; HOST DOPAMINERGIC AFFERENTS; BASAL GANGLIA; FOS EXPRESSION; BEHAVIORAL RECOVERY; HUNTINGTONS-DISEASE; PARKINSONS-DISEASE; MODULAR PATTERNS; MESSENGER-RNA; TISSUE GRAFTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Dunnett, SB UnivCambridgee, MRC, Cambridge Ctr Brain Repair, Forvie Site,Robinson Way, Univ Cambridge Forvie Site,Robinson Way Cambridge England CB22PY
Citazione:
S.B. Dunnett, "Striatal reconstruction by striatal grafts", J NEUR TR-S, (55), 1999, pp. 115-129

Abstract

It is now well established that striatal lesions induce motor and cognitive deficits in rats, and that grafts of embryonic striatal tissue can survive, integrate into the lesioned host brain and alleviate the behavioural deficits in both motor and cognitive spheres. How? Since normal striatal function is dependent upon it's integration within a connected cortical-subcortical neuronal circuitry, and the deficits following striatal damage appear to reflect a "disconnexion" syndrome, the observation of recovery suggests that the grafts re-establish a connected circuitry within the host brain. Evidence to corroborate or refute this hypothesis, in comparison with a less-specific mechanism (or mechanisms) of recovery, is considered, including anatomical, electrophysiological and neurochemical demonstrations of functional circuit reconstruction in the host brain by striatal tissue transplants.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 17:05:30