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Titolo:
Protective effects of the flavonoid mixture, silymarin, on fetal rat brainand liver
Autore:
La Grange, L; Wang, M; Watkins, R; Ortiz, D; Sanchez, ME; Konst, J; Lee, C; Reyes, E;
Indirizzi:
New Mexico Highlands Univ, Las Vegas, NM 87701 USA New Mexico Highlands Univ Las Vegas NM USA 87701 Las Vegas, NM 87701 USA Navajo Community Coll, Tsaile, AZ USA Navajo Community Coll Tsaile AZ USA avajo Community Coll, Tsaile, AZ USA Univ New Mexico, Sch Med, Albuquerque, NM 87131 USA Univ New Mexico Albuquerque NM USA 87131 h Med, Albuquerque, NM 87131 USA
Titolo Testata:
JOURNAL OF ETHNOPHARMACOLOGY
fascicolo: 1, volume: 65, anno: 1999,
pagine: 53 - 61
SICI:
0378-8741(199904)65:1<53:PEOTFM>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
SILIPIDE; COMPLEX; SILIBININ; SILYBIN;
Keywords:
fetal alcohol syndrome; Silymarin-Phytosome (R); gamma glutamyl transpeptidase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: La Grange, L New Mexico Highlands Univ, Las Vegas, NM 87701 USA New MexicoHighlands Univ Las Vegas NM USA 87701 M 87701 USA
Citazione:
L. La Grange et al., "Protective effects of the flavonoid mixture, silymarin, on fetal rat brainand liver", J ETHNOPHAR, 65(1), 1999, pp. 53-61

Abstract

We investigated the possibility that the flavonoid mixture, silymarin (SY), administered as the compound Silymarin-Phytosome(R) (PHYTO), could protect the fetus from maternally ingested EtOH. Seventy-six female rats were randomly assigned to one of seven groups: pair-fed control; chow fed control; EtOH; and four groups receiving EtOH and PHYTO in varying dosages. All groups except the chow-fed control were maintained on a liquid diet. On day 1 of pregnancy the dams began the treatment protocol. On day 21 of pregnancy the rats were sacrificed and the fetuses removed, Gamma glutamyl transpeptidase (GGTP) activity was determined for liver and brain tissue from both thefetuses and the dams. GGTP activity in the EtOH,silymarin treatment groupsdid nor differ significantly from that observed for the pair-fed control group. The observed GGTP activity levels for the EtOH-only group were significantly higher than those attained by the pair-fed control group. Although GGTP activity did not vary significantly with the quantity of PHYTO administered, as PHYTO dose was increased, GGTP activity decreased. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 03:29:55