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Titolo:
Subcellular heterogeneity of mitochondrial membrane potential: relationship with organelle distribution and intercellular contacts in normal, hypoxicand apoptotic cells
Autore:
Diaz, G; Setzu, MD; Zucca, A; Isola, R; Diana, A; Murru, R; Sogos, V; Gremo, F;
Indirizzi:
Univ Cagliari, Dept Cytomorphol, I-09124 Cagliari, Italy Univ Cagliari Cagliari Italy I-09124 ytomorphol, I-09124 Cagliari, Italy Univ Cagliari, Dept Med Sci, I-09124 Cagliari, Italy Univ Cagliari Cagliari Italy I-09124 pt Med Sci, I-09124 Cagliari, Italy
Titolo Testata:
JOURNAL OF CELL SCIENCE
fascicolo: 7, volume: 112, anno: 1999,
pagine: 1077 - 1084
SICI:
0021-9533(199904)112:7<1077:SHOMMP>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTRON-TRANSPORT CHAIN; PERMEABILITY TRANSITION; LEUKEMIC-CELLS; LIVING CELLS; HELA-CELLS; CALCIUM; LOCALIZATION; INHIBITION; GLUTAMATE; NECROSIS;
Keywords:
mitochondrion; membrane potential; acidic vesicle; cell edge; JC-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Diaz, G Univ Cagliari, Dept Cytomorphol, I-09124 Cagliari, Italy Univ Cagliari Cagliari Italy I-09124 ol, I-09124 Cagliari, Italy
Citazione:
G. Diaz et al., "Subcellular heterogeneity of mitochondrial membrane potential: relationship with organelle distribution and intercellular contacts in normal, hypoxicand apoptotic cells", J CELL SCI, 112(7), 1999, pp. 1077-1084

Abstract

The subcellular heterogeneity of mitochondrial membrane potential (m Deltapsi) was investigated in confluent and sub-confluent cultures of four celltypes (human astrocytes, HEp-2, MDCK and Vero cells) in normal growth conditions, hypoxia and apoptosis, The distribution of high-polarized mitochondria, detected by the potential-sensitive probe JC-1, was found to depend on: (1) the proximity to the cell edge; (2) the local absence of cell-cell contacts; and (3) the local absence of acidic vesicles. Both hypoxia and apoptosis produced a general m Delta psi increase with different redistributions of high-polarized mitochondria, Hypoxic cells maintained high-polarized mitochondria for over 24 hours, until cells underwent necrosis, On the otherhand, apoptotic cells showed an unexpected convergence of high-polarized mitochondria into an extremely packed mass at one side of the nucleus, in a stage preceding nuclear condensation, but correlated to the retraction of cell-cell contacts.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:59:53