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Titolo:
INVERSE CORRELATION BETWEEN IGG-ANTIHINGE REGION AND ANTIERYTHROCYTE AUTOANTIBODY IN CHRONIC BENIGN AND MALIGNANT COLD AGGLUTINATION
Autore:
TERNESS P; KIRSCHFINK M; NAVOLAN D; MORODER L; SIEDLER F; DRUGARIN D; SCHNEIDER F; DUFTER C; KOHL I; WELSCHOF M; OPELZ G; ROELCKE D;
Indirizzi:
UNIV HEIDELBERG,INST IMMUNOL,DEPT TRANSPLANTAT IMMUNOL,INF 305 D-69120 HEIDELBERG GERMANY UNIV MED & PHARM,DEPT PHYSIOL TIMISOARA ROMANIA MAX PLANCK INST BIOCHEM D-8033 MARTINSRIED GERMANY
Titolo Testata:
Journal of clinical immunology
fascicolo: 3, volume: 17, anno: 1997,
pagine: 220 - 227
SICI:
0271-9142(1997)17:3<220:ICBIRA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTI-IDIOTYPIC ANTIBODIES; LYMPHOMA-CELLS; ANTI-F(AB')(2); DORMANCY; SIGNALS; HLA;
Keywords:
COLD AGGLUTINATION; AUTOIMMUNITY; IGG; IMMUNOSUPPRESSION; IGG-ANTI-F(AB')(2);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
P. Terness et al., "INVERSE CORRELATION BETWEEN IGG-ANTIHINGE REGION AND ANTIERYTHROCYTE AUTOANTIBODY IN CHRONIC BENIGN AND MALIGNANT COLD AGGLUTINATION", Journal of clinical immunology, 17(3), 1997, pp. 220-227

Abstract

Previous reports provided evidence of an immunosuppressive role of natural anti-F(ab')(2) antibodies. If suppressive anti-F(ab')(2) antibodies also regulated the autoantibody production in cold agglutination, one would expect high titers of anti-F(ab')(2) to be associated with low titers of cold agglutinins. Indeed, our previous studies revealed an inverse correlation between IgG-anti-F(ab')(2) and cold agglutinins. Many previous experiments focused on anti-F(ab')(2) of an antiidiotypic nature. Recent epitope mapping showed that anti-F(ab')(2) of healthy persons is not an antiidiotype but recognizes a hinge region sequence. We attempted to answer the question whether this IgG-antihinge antibody is responsible for the previously described association between anti-F(ab')(2) and cold agglutinins. IgG-antihinge and IgG-anti-F(ab')(2) antibody was determined and statistically analyzed in the serum of 334 patients with cold agglutination. Our experiments revealed a strong correlation between the concentrations of antihinge and the previously described anti-F(ab')(2) antibody. The anti-F(ab')(2) activity was competitively inhibited by a synthetic hinge peptide. Moreover, patients with high antihinge titers had low cold agglutinin titers, and viceversa. A stratification according to cold agglutinin specificity and disease etiology showed that the inverse correlation is present only in anti-I and anti-i patients suffering from monoclonal B-lymphocyte proliferation. In conclusion, our results confirm the correlation previously described for anti-F(ab')(2) antibody and antierythrocyte autoantibody and define for the first time an association between an idiotype-independent anti-IgG autoantibody and cold agglutinin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 14:05:18