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Titolo:
Predominance of CCR5-dependent HIV-1 subtype E isolates in Cambodia
Autore:
Menu, E; Reynes, JM; Muller-Trutwin, MC; Guillemot, L; Versmisse, P; Chiron, M; An, S; Trouplin, V; Charneau, P; Fleury, H; Barre-Sinoussi, F; Sainte Marie, FF;
Indirizzi:
Inst Pasteur, Unite Biol Retrovirus, F-75724 Paris 15, France Inst Pasteur Paris France 15 e Biol Retrovirus, F-75724 Paris 15, France Hop Antoine Beclere, INSERM, U131, Clamart, France Hop Antoine Beclere Clamart France clere, INSERM, U131, Clamart, France Inst Pasteur Cambodge, Phnom Penh, Cambodia Inst Pasteur Cambodge Phnom Penh Cambodia ambodge, Phnom Penh, Cambodia Tuol Kork, Local Hlth Serv, Phnom Penh, Cambodia Tuol Kork Phnom Penh Cambodia rk, Local Hlth Serv, Phnom Penh, Cambodia Inst Pasteur, Unite Oncol Virale, F-75724 Paris, France Inst Pasteur Paris France F-75724 te Oncol Virale, F-75724 Paris, France Univ Bordeaux 2, Virol Lab, F-33076 Bordeaux, France Univ Bordeaux 2 Bordeaux France F-33076 ol Lab, F-33076 Bordeaux, France
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY
fascicolo: 5, volume: 20, anno: 1999,
pagine: 481 - 487
SICI:
1525-4135(19990415)20:5<481:POCHSE>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; HETERODUPLEX MOBILITY ASSAY; LANGERHANS CELL TROPISM; GENOTYPIC CHARACTERISTICS; INFECTION; PHENOTYPE; THAILAND; RISK; TRANSMISSION; PROGRESSION;
Keywords:
HIV-1; subtype E; HIV-1 coreceptors; viral population dynamics; Cambodia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Barre-Sinoussi, F Instceasteur, Unite Biol Retrovirus, 25 Rue Dr Roux, F-75724 Paris 15, Fran Inst Pasteur 25 Rue Dr Roux Paris France 15 is 15, Fran
Citazione:
E. Menu et al., "Predominance of CCR5-dependent HIV-1 subtype E isolates in Cambodia", J ACQ IMM D, 20(5), 1999, pp. 481-487

Abstract

To investigate the genetic and biologic features of HIV-I strains circulating in Cambodia, viruses from 95 HIV-l-seropositive individuals were subtyped by heteroduplex mobility assay (HMA) and 23 were further analyzed for their biologic characteristics. Eighty-nine individuals were clearly infectedby HIV-1 subtype E. The other six samples were sequenced, together with 17HMA subtype E samples. All but one of the 23 Cambodian env sequences clustered with previously described Thai and Vietnamese subtype E sequences, bearing a GPGQ motif at the tip of the V3 loop; the last had a GPGR motif and was phylogenetically equidistant from Asian and African subtype E viruses. Nonsyncytium-inducing, CCR5-dependent viruses predominated in patients of clinical stage B even in some with a high viral load and were detected in about 50% of the patients of stage C. All syncytium-inducing strains, mostly from AIDS patients, used both CCR5 and CXCR4. The presence of syncytium-inducing viruses did not correlate with the plasma viral load. These data showthat CCR5-dependent HIV-I subtype E is currently predominant in Cambodia. The analysis of clinical and virologic markers strongly supports the idea that dynamics of the viral population during subtype E infection in Southeast Asia is similar to that of subtype B infection in Europe and the United States.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 02:29:28