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Titolo:
Cellular immune responses to Neisseria meningitidis in children
Autore:
Pollard, AJ; Galassini, R; van der Voort, EMR; Hibberd, M; Booy, R; Langford, P; Nadel, S; Ison, C; Kroll, JS; Poolman, J; Levin, M;
Indirizzi:
St,Marys Hosp, Sch Med, Imperial Coll, Dept Paediat,Paediat Infect Dis Unit St Marys Hosp London England W2 1PG Dept Paediat,Paediat Infect Dis Unit StW2arys Hosp, Sch Med, Imperial Coll, Dept Microbiol & Infect Dis, LondonSt Marys Hosp London England W2 1PG Dept Microbiol & Infect Dis, London Natl0Inst Publ Hlth & Environm, Lab Vaccine Dev & Immune Mechanisms, NL-372 Natl Inst Publ Hlth & Environm Bilthoven Netherlands NL-3720 BA , NL-372
Titolo Testata:
INFECTION AND IMMUNITY
fascicolo: 5, volume: 67, anno: 1999,
pagine: 2452 - 2463
SICI:
0019-9567(199905)67:5<2452:CIRTNM>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEMBRANE VESICLE VACCINE; PROTEIN CONJUGATE VACCINE; SIMPLEX VIRUS-INFECTION; CD4 T-CELLS; INTERFERON-GAMMA; WHOLE-CELL; MONOCLONAL-ANTIBODIES; MENINGOCOCCAL VACCINE; DECREASED PRODUCTION; SYNTHETIC PEPTIDES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Pollard, AJ St,Marys Hosp, Sch Med, Imperial Coll, Dept Paediat,Paediat Infect Dis Unit St Marys Hosp Norfolk Pl London England W2 1PG nfect Dis Unit
Citazione:
A.J. Pollard et al., "Cellular immune responses to Neisseria meningitidis in children", INFEC IMMUN, 67(5), 1999, pp. 2452-2463

Abstract

There is an urgent need for effective vaccines against serogroup B Neisseria Meningitidis. Current experimental vaccines based on the outer membrane proteins (OMPs) of this organism provide a measure of protection in older children but have been ineffective in infants. We postulated that the inability of OMP vaccines to protect infants might be due to age-dependent defects in cellular immunity, We measured proliferation and in vitro production of gamma interferon (IFN-gamma), tumor necrosis factor alpha, and interleukin-10 (IL-10) in response to meningococcal antigens by peripheral blood mononuclear cells (PBMCs) from children convalescing from meningococcal diseaseand from controls. After meningococcal infection, the balance of cytokine production by PBMCs from the youngest children was skewed towards a T(H)1 response (low IL-10/ IFN-gamma ratio), while older children produced more T(H)2 cytokine (higher IL-10/IFN-gamma ratio). There was a trend to higher proliferative responses by PBMCs from older children. These responses,were not influenced by the presence or subtype of class 1 (PorA) OMP or by the presence of class 2/3 (PorB) or class 4 OMP, Even young infants might be expected to develop adequate cellular immune responses to serogroup B N. meningitidis vaccines if a vaccine preparation can be formulated to mimic the immune stimulus of invasive disease, which may include stimulation of T(H)2 cytokine production.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:26:52