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Titolo:
Identification of multiple HIV-1 CTL epitopes presented by HLA-B*5101 molecules
Autore:
Tomiyama, H; Sakaguchi, T; Miwa, K; Oka, S; Iwamoto, A; Kaneko, Y; Takiguchi, M;
Indirizzi:
Kumamoto Univ, Ctr AIDS Res, Div Viral Immunol, Kumamoto 862, Japan Kumamoto Univ Kumamoto Japan 862 Div Viral Immunol, Kumamoto 862, Japan Univ Tokyo, Dept Tumor Biol, Tokyo 108, Japan Univ Tokyo Tokyo Japan 108Univ Tokyo, Dept Tumor Biol, Tokyo 108, Japan Univ Tokyo, Inst Med Sci, Dept Infect Dis, Tokyo 108, Japan Univ Tokyo Tokyo Japan 108 st Med Sci, Dept Infect Dis, Tokyo 108, Japan Int Med Ctr Japan, AIDS Clin Ctr, Tokyo 162, Japan Int Med Ctr Japan Tokyo Japan 162 Japan, AIDS Clin Ctr, Tokyo 162, Japan Ajinomoto Pharmaceut Labs, Kanagawa 220, Japan Ajinomoto Pharmaceut Labs Kanagawa Japan 220 t Labs, Kanagawa 220, Japan
Titolo Testata:
HUMAN IMMUNOLOGY
fascicolo: 3, volume: 60, anno: 1999,
pagine: 177 - 186
SICI:
0198-8859(199903)60:3<177:IOMHCE>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-LYMPHOCYTE EPITOPES; HLA-CLASS-I; IMMUNODEFICIENCY-VIRUS; CONSERVED REGION; IMMUNE-RESPONSES; PEPTIDE MOTIFS; CELL EPITOPES; NEF PROTEIN; INFECTION; ASSOCIATION;
Keywords:
HIV-1; CTL epitope; HLA-B*5101; CTL clone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Takiguchi, M Kumamoto2,niv, Ctr AIDS Res, Div Viral Immunol, 4-24-1 Kubonji, Kumamoto 86 Kumamoto Univ 4-24-1 Kubonji Kumamoto Japan 862 Kumamoto 86
Citazione:
H. Tomiyama et al., "Identification of multiple HIV-1 CTL epitopes presented by HLA-B*5101 molecules", HUMAN IMMUN, 60(3), 1999, pp. 177-186

Abstract

We attempted to identify and characterize HIV-1 CTL epitopes presented by HLA-B51 which is associated with a slow progression to AIDS. HLA-B*5101 stabilization assay showed that 33 out of 172 HIV-1 peptides carrying HLA-B*5101 anchor residues bound to HLA-B*5101. Seven peptides mere suggested as HIV-1 CTL epitopes presented by HLA-B*5101 because the specific CTL was induced for these peptides in PBMC from three HIV-1 seropositive individuals carrying HLA-B51 by stimulation with HLA-B*5101 binding peptides. Analysis of these epitopes using the specific CTL clones confirmed that six of seven HIV-1 peptides are epitopes presented by HLA-B*5101. Three epitopes presentedby HLA-B*5101 are highly conserved among the clade B strain, suggesting that the specific CTL for these epitopes might play an important role in recognition of HIV-1 infected cells. These epitopes will be useful to analyze CTL responses in HIV-1 infected individuals. Human Immunology 60, 177-186 (1999). (C) American Society for Histocompatibility and Immunogenetics, 1999. Published by Elsevier Science Inc.

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Documento generato il 24/09/20 alle ore 08:20:27