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Titolo:
Interest of pelvic and paraaortic lymphadenectomy in patients with stage IB and II cervical carcinoma
Autore:
Morice, P; Castaigne, D; Pautier, P; Rey, A; Haie-Meder, C; Leblanc, M; Duvillard, P;
Indirizzi:
Inst4805tave Roussy, Dept Gynecol Surg Oncol Biostat Radiotherapy & Pa, F-9 Inst Gustave Roussy Villejuif France F-94805 stat Radiotherapy & Pa, F-9
Titolo Testata:
GYNECOLOGIC ONCOLOGY
fascicolo: 1, volume: 73, anno: 1999,
pagine: 106 - 110
SICI:
0090-8258(199904)73:1<106:IOPAPL>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPH-NODE METASTASES; PROGNOSTIC-SIGNIFICANCE; RADICAL HYSTERECTOMY; RADIATION-THERAPY; UTERINE CERVIX; CANCER; INVOLVEMENT; RESECTION;
Keywords:
carcinoma of the cervix; lymphadenectomy; prognostic factors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Morice, P Inst4805tave Roussy, Dept Gynecol Surg Oncol Biostat Radiotherapy & Pa, F-9 Inst Gustave Roussy Villejuif France F-94805 therapy & Pa, F-9
Citazione:
P. Morice et al., "Interest of pelvic and paraaortic lymphadenectomy in patients with stage IB and II cervical carcinoma", GYNECOL ONC, 73(1), 1999, pp. 106-110

Abstract

Objectives. The objectives of this study were to evaluate the interest andthe potential therapeutic value of systematic pelvic and paraaortic lymphadenectomy in patients with stage Ib and II cervical carcinoma. Methods. This was a prospective study including 421 patients with cervicalcancer treated, from 1985 to 1994, by combined radiation therapy and surgery with systematic pelvic and paraaortic lymphadenectomy. Results. The overall rate of pelvic lymph-node involvement was 26% (106 patients), and the rate of paraaortic metastases was 8% (32 patients). Pelvicnodal involvement was unilateral in 14% (59 patients) and bilateral in 11%(47 patients). Macroscopic positive nodes were found in 12% (52 patients). In a univariate analysis, a young age (<30 years), a tumor size greater than or equal to 4 cm, stage II disease, and nodal involvement were associated with significantly decreased survival. The nodal status and the characteristics of positive nodes (number and location) were the most significant prognostic factors. In the multivariate analysis, age, the tumor size, and the site of nodal involvement (pelvic or paraaortic) were prognostic factors. Three-year survival was 94% for patients with negative nodes compared to 64% for patients with positive pelvic nodes and 35% for patients with positive paraaortic nodes (P < 0.0001). Conclusion. These results confirm the diagnostic and prognostic value of systematic complete lymphadenectomy when planning adjuvant treatment and thetherapeutic value of complete removal of bulky positive nodes. (C) 1999 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 02:59:30