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Titolo:
Influence of age on the clinical presentation of prolactinomas in male patients
Autore:
Delgrange, E; Maiter, D; Donckier, J; Tourniaire, J;
Indirizzi:
UnivelgiumUCL Mont Godinne, Dept Internal Med & Endocrinol, B-5530 Yvoir, B Univ Hosp UCL Mont Godinne Yvoir Belgium B-5530 ocrinol, B-5530 Yvoir, B Univ Catholique Louvain, Dept Endocrinol & Nutr, B-1200 Brussels, Belgium Univ Catholique Louvain Brussels Belgium B-1200 B-1200 Brussels, Belgium Univ Lyon 1, Hop Atiquaille, Clin Endocrinol, Lyon, France Univ Lyon 1 Lyon France , Hop Atiquaille, Clin Endocrinol, Lyon, France
Titolo Testata:
GERONTOLOGY
fascicolo: 3, volume: 45, anno: 1999,
pagine: 160 - 164
SICI:
0304-324X(199905/06)45:3<160:IOAOTC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-TUMORS; HYPERPROLACTINEMIC HYPOGONADISM; CABERGOLINE; HYPOPITUITARISM; OSTEOPOROSIS; MANAGEMENT; RESISTANT; DIAGNOSIS; RESPOND; MEN;
Keywords:
prolactin-secreting adenoma; age; hypopituitarism; dopamine agonists;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Delgrange, E UnivelgiumUCL Mont Godinne, Dept Internal Med & Endocrinol, B-5530 Yvoir, B Univ Hosp UCL Mont Godinne Yvoir Belgium B-5530 30 Yvoir, B
Citazione:
E. Delgrange et al., "Influence of age on the clinical presentation of prolactinomas in male patients", GERONTOLOGY, 45(3), 1999, pp. 160-164

Abstract

Objective: Secreting pituitary adenomas are usually not considered a disease of older people. However, in male patients, prolactin-secreting pituitary tumours occur at a similar frequency throughout the entire life span, giving the opportunity to study in this gender the influence of age on the clinical presentation and response to treatment of these tumours. Methods: We conducted a retrospective study including 9 male patients aged greater thanor equal to 60 (range 60-73) years and 10 aged less than or equal to 30 (range 17-30) years presenting with a prolactinoma in order to compare clinical presentation, results of pituitary function tests, and response to dopamine agonist therapy between older and younger patients. Results: Four of the 9 elderly as well as the 10 younger patients came to medical attention for typical features of male prolactinomas including visual field defect in 5(2 elderly), headaches in 2 (1 elderly), impotence in 3 (1 elderly), gynaecomastia and/or galactorrhoea in 2, and arrested puberty in 2. The remaining 5 older people presented for other various reasons: symptoms related to cortisol deficiency in 2, lethargy with clinical signs of hypopituitarism in1, spontaneous multiple vertebral fractures in 1, and incidental discoveryof a pituitary mass in 1. Basal prolactin levels (3,051 +/- 4,151 vs. 3,365 +/- 4,949 mu g/l) and mean tumour diameter (30 +/- 16 vs. 25 +/- 13 mm) were similar in old and young patients. Cortisol deficiency was significantly more frequent in the elderly (n = 6) than in the young (n = 1) patients (p 0.02, Fisher's exact test). Secondary hypothyroidism was found in 2 elderly only, but not in young patients. Sixteen patients (8 elderly) received bromocriptine therapy for at least 6 months with a good tolerance. Normalization of the prolactin levels was achieved in 6 older (75%) and 4 younger patients (50%). Conclusions: The presentation of a prolactinoma in the elderly man is very heterogeneous and can be misleading. At the time of diagnosis, hypopituitarism is more frequent among older than younger patients despite a similar tumour size. We found dopamine agonists equally effective in the elderly.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 06:19:11