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Titolo:
The Sox-13 gene: Structure, promoter characterization, and chromosomal localization
Autore:
Roose, J; Korver, W; de Boer, R; Kuipers, J; Hurenkamp, J; Clevers, H;
Indirizzi:
Univ Utrecht Hosp, Dept Immunol, NL-3508 GA Utrecht, Netherlands Univ Utrecht Hosp Utrecht Netherlands NL-3508 GA GA Utrecht, Netherlands
Titolo Testata:
GENOMICS
fascicolo: 2, volume: 57, anno: 1999,
pagine: 301 - 305
SICI:
0888-7543(19990415)57:2<301:TSGSPC>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
SRY-RELATED GENE; AUTOSOMAL SEX REVERSAL; CAMPOMELIC DYSPLASIA; EXPRESSION; MOUSE; MUTATIONS; CLONING; PROTEIN; TISSUE; MEMBER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Roose, J Univ Utrecht Hosp, Dept Immunol, POB 85500, NL-3508 GA Utrecht, Netherlands Univ Utrecht Hosp POB 85500 Utrecht Netherlands NL-3508 GA lands
Citazione:
J. Roose et al., "The Sox-13 gene: Structure, promoter characterization, and chromosomal localization", GENOMICS, 57(2), 1999, pp. 301-305

Abstract

We have recently identified the HMG box transcription factor Sox-13 and described its expression during murine embryogenesis. Here we describe the structure of the murine Sox-IS gene. This gene spans approximately 12 kb and consists of 13 exons. The HMG domain is encoded by exons XI and XII, separated by an intron that is conserved among Sox-5, Sox-IS, and Sox-17. A single major transcription initiation site was identified. Deletion analysis of the 3-kb promoter region revealed a 400-bp fragment driving transcription of a luciferase reporter in a Sox-IS-expressing cell line. To determine the chromosomal localization of the human gene, a human SOX13 cDNA was isolatedwith 75% homology to the mouse Sox-IS. FISH analysis mapped the human SOX13 gene to chromosome 1 band q32. (C) 1999 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 06:43:36