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Titolo:
New 9- or 10-arylpiperazinoalkyl substituted pyrimido- or diazepino[2,1-f]purines with partial or full 5-HT1A agonistic activity
Autore:
Pawlowski, M; Katlabi, J; Drabczynska, A; Duszynska, B; Charakchieva-Minol, S; Deren-Wesolek, A; Tatarczynska, E; Chojnacka-Wojcik, E; Mokrosz, MJ; Bojarski, AJ;
Indirizzi:
Jagiellonian Univ, Coll Med, Dept Pharmaceut Chem, PL-30688 Krakow, PolandJagiellonian Univ Krakow Poland PL-30688 t Chem, PL-30688 Krakow, Poland Polish Acad Sci, Inst Pharmacol, PL-31343 Krakow, Poland Polish Acad Sci Krakow Poland PL-31343 harmacol, PL-31343 Krakow, Poland
Titolo Testata:
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
fascicolo: 2, volume: 34, anno: 1999,
pagine: 167 - 175
SICI:
0223-5234(199902)34:2<167:N9O1SP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTSYNAPTIC 5-HT(1A) RECEPTORS; SELECTIVE ANTAGONIST; MICE; AFFINITY; LIGANDS; AGENTS; MODEL;
Keywords:
1-arylpiperazine; 5-HT1A agonists; pyrimidopurines; diazepinopurines;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Pawlowski, M JagiellonianKrakow,Coll Med, Dept Pharmaceut Chem, 9 MedycznaSt, PL-30688 Jagiellonian Univ 9 Medyczna St Krakow Poland PL-30688 30688
Citazione:
M. Pawlowski et al., "New 9- or 10-arylpiperazinoalkyl substituted pyrimido- or diazepino[2,1-f]purines with partial or full 5-HT1A agonistic activity", EUR J MED C, 34(2), 1999, pp. 167-175

Abstract

5HT(1A) and 5HT(2A) receptor affinities of several gamma-(3'-chloro- or 2'-methoxyphenyl)-piperazinopropyl derivatives of pyrimido[2,1-f]purines or 1,3-diazepino[2,1-f]purines are reported. Some behavioral models demonstrated that 1,3-dimethyl-9-{3-[4-(2'-methoxyphenyl)-1-piperazinyl]propyl}-2,4-dioxo-1,3,6,7,8,9-hexahydropyrimido[2,1-f]purine 5b and 1,3-dimethyl-9-{3-[4-(2'-methoxyphenyl)-1-piperazinyl]propyl}-2,4,8-trioxo-1,3-dihydro-9H-pyrimido[2,1-f]purine 8b, may be classified as partial agonist and a full agonist, respectively of pre- and post-synaptic 5HT(1A) receptors. (C) Elsevier, Paris.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 14:56:11