Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Epidemiologic approaches to the study of Parkinson's disease etiology
Autore:
Checkoway, H; Nelson, LM;
Indirizzi:
Univ,Washington, Dept Environm Hlth, Sch Publ Hlth & Community Med, Seattle Univ Washington Seattle WA USA 98195 h Publ Hlth & Community Med, Seattle Stanford Univ, Sch Med, Dept Hlth Res & Policy, Div Epidemiol, Stanford, CA Stanford Univ Stanford CA USA 94305 & Policy, Div Epidemiol, Stanford, CA
Titolo Testata:
EPIDEMIOLOGY
fascicolo: 3, volume: 10, anno: 1999,
pagine: 327 - 336
SICI:
1044-3983(199905)10:3<327:EATTSO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOAMINE-OXIDASE-B; ENVIRONMENTAL RISK-FACTORS; HYDROXYLASE GENE POLYMORPHISM; AMYOTROPHIC-LATERAL-SCLEROSIS; CYP2D6 ALLELIC FREQUENCIES; CIGARETTE-SMOKING; YOUNG-ONSET; SUPEROXIDE-DISMUTASE; APOLIPOPROTEIN-E; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE MPTP;
Keywords:
Parkinson's disease; smoking; environmental exposures; generic polymorphisms; etiology;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
157
Recensione:
Indirizzi per estratti:
Indirizzo: Checkoway, H Univ234,hington, Dept Environm Hlth, Sch Publ Hlth & Community Med, Box 357 Univ Washington Box 357234 Seattle WA USA 98195 Med, Box 357
Citazione:
H. Checkoway e L.M. Nelson, "Epidemiologic approaches to the study of Parkinson's disease etiology", EPIDEMIOLOG, 10(3), 1999, pp. 327-336

Abstract

The etiology of Parkinson's disease has been enigmatic to clinicians, epidemiologists, and basic scientists since the clinical syndrome was first described in 1817. Mendelian inheritance probably accounts fur a small proportion of Parkinson's disease. Apart from an increasing risk with age, the most consistent epidemiologic observation has been an inverse relation with cigarette smoking. Neither selective survival of nonsmokers nor behavioral characteristics of smokers can explain this seemingly protective association,interest in environmental exposures, particularly pesticides, metals, and industrial solvents, heightened substantially following the discovery of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a street drug contaminant, as a cause of human parkinsonism. Epidemiologic and toxicologic researchhas since been guided to a great extent, although not exclusively, by mechanisms of MPTP toxicity. Efforts to characterize gene/environment interactions have also intensified in recent years. In this review, we evaluate recent evidence concerning the etiology of Parkinson's disease, with emphasis on environmental and lifestyle exposures and their potential interactions with genetic susceptibility traits. The most challenging aspects of epidemiologic research into Parkinson's disease causation include methodologic difficulties surrounding case definition, completeness of case ascertainment, selection of appropriate controls in case-control studies, and assessment of environmental exposures. We conclude with recommendations for future research directions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:15:52