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Titolo:
Neural and behavioral effects of intracranial 192 IgG-saporin in neonatal rats: sexually dimorphic effects?
Autore:
Sherren, N; Pappas, BA; Fortin, T;
Indirizzi:
Carleton Univ, Inst Neurosci, Life Sci Res Ctr, Ottawa, ON K1S 5B6, CanadaCarleton Univ Ottawa ON Canada K1S 5B6 es Ctr, Ottawa, ON K1S 5B6, Canada
Titolo Testata:
DEVELOPMENTAL BRAIN RESEARCH
fascicolo: 1, volume: 114, anno: 1999,
pagine: 49 - 62
SICI:
0165-3806(19990412)114:1<49:NABEOI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOREBRAIN CHOLINERGIC NEURONS; GROWTH-FACTOR RECEPTOR; ABNORMAL CORTICAL DEVELOPMENT; MUSTARD AZIRIDINIUM AF64A; BASAL FOREBRAIN; NGF RECEPTOR; RETT-SYNDROME; SEPTOHIPPOCAMPAL NEURONS; LESIONS; SYSTEM;
Keywords:
acetylcholine; basal forebrain; brain development; Rett syndrome; sex difference; sympathetic ingrowth;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Pappas, BA Carleton Univ, Inst Neurosci, Life Sci Res Ctr, 1125 Colonel Dr, Ottawa, ON Carleton Univ 1125 Colonel Dr Ottawa ON Canada K1S 5B6 tawa, ON
Citazione:
N. Sherren et al., "Neural and behavioral effects of intracranial 192 IgG-saporin in neonatal rats: sexually dimorphic effects?", DEV BRAIN R, 114(1), 1999, pp. 49-62

Abstract

The consequences of neonatal cholinergic lesions were examined in male andfemale rats. Rats were injected intraventricularly with 600 ng of 192 IgG-saporin at 7 days of age and examined behaviorally and histologically at 21, 45 and 90 days of age. 192 IgG-saporin profoundly reduced low affinity neurotrophin receptor (p75(NTR))-immunoreactive (LR) and, to a lesser extent,choline acetyltransferase-IR cells in the basal forebrain. Presumptive sympathetic ingrowths (p75(NTR)- and dopamine beta-hydroxylase-IR) into the hippocampus were first apparent at 45 days of age and were not significantly greater at 90 days. Behaviorally, 192 IgG-saporin increased the time females, but not males, spent on the open arms of the elevated plus maze. Lesioned rats had longer platform location latencies in the Morris water maze onlyat the first hidden platform training session and did not differ on the rate of learning the platform location or on the no-platform probe trial. Generally, the effects of neonatal cholinergic lesions were not sex dependent and are unlikely to model Rett syndrome, a disorder characterized by forebrain cholinergic deficit which is seen almost exclusively in females. (C) 1999 Elsevier Science B.V. All rights reserved.

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Documento generato il 26/01/20 alle ore 10:10:48