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Titolo:
DISTRIBUTION OF INOSITOL-1,4,5-TRISPHOSPHATE AND RYANODINE RECEPTORS IN RAT NEOSTRIATUM
Autore:
MARTONE ME; ALBA SA; EDELMAN VM; AIREY JA; ELLISMAN MH;
Indirizzi:
UNIV CALIF SAN DIEGO,DEPT NEUROSCI LA JOLLA CA 92093 UNIV NEVADA,DEPT PHARMACOL RENO NV 89557
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 756, anno: 1997,
pagine: 9 - 21
SICI:
0006-8993(1997)756:1-2<9:DOIARR>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; CEREBELLAR PURKINJE NEURONS; CA2+ RELEASE CHANNELS; IMMUNOHISTOCHEMICAL LOCALIZATION; SYMPATHETIC NEURONS; HUNTINGTONS-DISEASE; DENDRITIC SPINES; CALCIUM-RELEASE; INTRACELLULAR CALCIUM;
Keywords:
CAUDATE PUTAMEN; INTERNEURON; SPINY NEURON; INTRACELLULAR CALCIUM; ENDOPLASMIC RETICULUM; DENDRITIC SPINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
M.E. Martone et al., "DISTRIBUTION OF INOSITOL-1,4,5-TRISPHOSPHATE AND RYANODINE RECEPTORS IN RAT NEOSTRIATUM", Brain research, 756(1-2), 1997, pp. 9-21

Abstract

The distribution of the inositol-1,4,5-trisphosphate (IP3) and the cardiac form of the ryanodine receptor, two intracellular calcium channels, was examined in the rat neostriatum. Both IP3 and ryanodine receptor labeling occurred within striatal medium spiny cells but only ryanodine receptor labeling was present in choline acetyltransferase- and parvalbumin-positive; interneurons. IP3 receptor labeling was observed within cell bodies, dendrites and spines of spiny striatal neurons, asseen at both the light and electron microscopic levels. Subcellular labeling for the ryanodine receptor was restricted to cell bodies and proximal dendrites when a polyclonal antibody raised against a peptide sequence from the dog cardiac ryanodine receptor was employed. More extensive dendritic labeling was seen using monoclonal antibody MA3-916,also raised against the canine cardiac ryanodine receptor. At the ultrastructural level, labeled dendritic spines were observed frequently with the monoclonal but not the polyclonal antibody. Ryanodine receptor labeling also was present within astrocytic processes surrounding blood vessels and within the neuropil, regardless of the antibody used. The results of these studies suggest that the ryanodine receptor playsa general role in intracellular calcium regulation within striatal cells while the IP3 receptor plays a specialized role within spiny neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 15:56:09