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Titolo:
Macrophages, lipoprotein metabolism, and atherosclerosis: insights from murine bone marrow transplantation studies
Autore:
Linton, MF; Fazio, S;
Indirizzi:
Vanderbilt7232v, Med Ctr, Sch Med, Div Endocrinol,Dept Med, Nashville, TN 3 Vanderbilt Univ Nashville TN USA 37232 docrinol,Dept Med, Nashville, TN 3 Vanderbilt32niv, Med Ctr, Dept Pharmacol, Div Endocrinol, Nashville, TN 372 Vanderbilt Univ Nashville TN USA 37232 Div Endocrinol, Nashville, TN 372 VanderbiltUSAiv, Med Ctr, Dept Pathol, Div Endocrinol, Nashville, TN 37232Vanderbilt Univ Nashville TN USA 37232 iv Endocrinol, Nashville, TN 37232
Titolo Testata:
CURRENT OPINION IN LIPIDOLOGY
fascicolo: 2, volume: 10, anno: 1999,
pagine: 97 - 105
SICI:
0957-9672(199904)10:2<97:MLMAAI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; E-DEFICIENT MICE; HEPARAN-SULFATE PROTEOGLYCANS; ISOLATED HUMAN LYMPHOCYTES; RECEPTOR KNOCKOUT MICE; HUMAN APOLIPOPROTEIN-E; CHYLOMICRON REMNANTS; APOPROTEIN-E; FAMILIAL HYPERCHOLESTEROLEMIA; TRANSGENIC MICE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Linton, MF VanderbiltgUniv, Med Ctr, Sch Med, Div Endocrinol,Dept Med, 715Med Res Bld Vanderbilt Univ 715 Med Res Bldg 2 Nashville TN USA 37232 s Bld
Citazione:
M.F. Linton e S. Fazio, "Macrophages, lipoprotein metabolism, and atherosclerosis: insights from murine bone marrow transplantation studies", CURR OP LIP, 10(2), 1999, pp. 97-105

Abstract

The macrophage expresses a variety of genes that may contribute to lipoprotein metabolism and atherosclerotic lesion formation. Bone marrow transplantation experiments using gene-targeted mice, both as donors and recipients,provide a useful approach to examine the contribution of macrophage gene expression to lipoprotein metabolism and atherogenesis in vivo. This articledescribes recent insights into the role of macrophage expression of apolipoprotein E and the LDL receptor gained from bone marrow transplantation studies in the mouse, Curr Opin Lipidol 10:97-105. (C) 1999 Lippincott Williams & Wilkins.

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Documento generato il 04/12/20 alle ore 06:31:46